Document Detail


Angioplasty of Obstructed Homograft Conduits in the Right Ventricular Outflow Tract With Ultra-Noncompliant Balloons: Assessment of Therapeutic Efficacy and Conduit Tears.
MedLine Citation:
PMID:  24254707     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: ANGIOPLASTY AND STENT PLACEMENT IN RIGHT VENTRICLE-TO-PULMONARY ARTERY (RV-PA) CONDUITS HAVE BEEN SHOWN TO PROLONG THE FUNCTIONAL LIFESPAN OF A CONDUIT. SAFETY AND EFFICACY OF ANGIOPLASTY OF OBSTRUCTED RV-PA HOMOGRAFTS USING ULTRA-NONCOMPLIANT (UNC) OR ULTRAHIGH-PRESSURE BALLOONS ARE UNKNOWN.METHODS AND RESULTS: FROM 2004 TO 2012, 70 PATIENTS UNDERWENT 76 PROCEDURES FOR ANGIOPLASTY OF RV-PA HOMOGRAFTS WITH UNCATLAS BALLOONS. THE UNC GROUP WAS COMPARED WITH A PARTIALLY CONTEMPORANEOUS CONTROL COHORT OF 81 PATIENTS WHO UNDERWENT 84 ANGIOPLASTY PROCEDURES WITH CONVENTIONAL BALLOONS. ACUTE HEMODYNAMIC CHANGES AFTER ANGIOPLASTY OF HOMOGRAFTS WITH UNC BALLOONS INCLUDED SIGNIFICANTLY REDUCED RV:AO PRESSURE RATIO (P=0.02) AND RIGHT VENTRICULAR OUTFLOW TRACT GRADIENTS (P0.001). BALLOON WAIST RESOLUTION WAS MORE FREQUENTLY ACHIEVED WITH UNC BALLOONS (P=0.04), AND BALLOON RUPTURE OCCURRED LESS OFTEN (P0.001). CONDUIT TEARS OF ANY SEVERITY OCCURRED IN 22% OF PATIENTS OVERALL AND WERE MORE COMMON IN THE UNC GROUP (P=0.001). PATIENTS WITH ANY CONDUIT TEAR HAD SIGNIFICANTLY GREATER REDUCTION IN THEIR RV:AO PRESSURE RATIO (P0.001) AND RIGHT VENTRICULAR OUTFLOW TRACT GRADIENT (P=0.004) THAN THOSE WITH NO TEAR. THERE WERE 4 UNCONFINED TEARS, ALL IN THE UNC GROUP, WITH NO ACUTE DECOMPENSATIONS OR DEATHS AND ONLY 1 PATIENT WHO REQUIRED SURGICAL MANAGEMENT.CONCLUSIONS: RV-PA conduit tears are common in patients undergoing angioplasty, but clinically important tears, which only occurred during UNC angioplasty in this series, were uncommon. UNC balloons can be used to good effect with significant reduction in right ventricular outflow tract gradient and the RV:Ao ratio when compared with conventional balloons.
Authors:
Michael R Hainstock; Audrey C Marshall; James E Lock; Doff B McElhinney
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-19
Journal Detail:
Title:  Circulation. Cardiovascular interventions     Volume:  -     ISSN:  1941-7632     ISO Abbreviation:  Circ Cardiovasc Interv     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101499602     Medline TA:  Circ Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatric Cardiology, Children's Hospital Boston, MA.
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