Document Detail

Angioleiomyoma affecting the lips: Report of 3 cases and review of the literature.
MedLine Citation:
PMID:  20526260     Owner:  NLM     Status:  In-Data-Review    
Angioleiomyoma is an uncommon benign soft tissue tumor usually found in the lower extremities and rarely observed in oral tissues. It is microscopically characterized as a proliferation of smooth muscle cells intermingled with abundant vascular channels. Oral angioleiomyomas affect mostly the lips, palate, buccal mucosa and tongue, and appears as a submucosal painless nodule. Upper lip is seldom affected and only few cases have been reported. We report three additional cases of angioleiomyoma affecting the lips of elderly patients. All lesions were asymptomatic and presented as submucosal nodules of approximately 1cm. Microscopic analysis on H&E sections revealed similar pattern in all cases, showing well-circumscribed and encapsulated tumors characterized by proliferation of smooth muscle cells and large amount of wide vascular spaces of varying sizes. Most tumor cells were immunoreactive for a-smooth muscle actin, desmin and HHF-35. CD34 was also positive on the endothelial cells. All patients were surgically treated and no recurrence was observed so far. The oral pathologists and clinicians should consider this entity when assessing nodular lesions on upper lip.
L-A Gueiros; M-J Romañach; A-M Pires-Soubhia; F-R Pires; O Paes-de-Almeida; P-A Vargas
Publication Detail:
Type:  Journal Article     Date:  2011-07-01
Journal Detail:
Title:  Medicina oral, patología oral y cirugía bucal     Volume:  16     ISSN:  1698-6946     ISO Abbreviation:  Med Oral Patol Oral Cir Bucal     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231694     Medline TA:  Med Oral Patol Oral Cir Bucal     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  e482-7     Citation Subset:  D; IM    
Department of Oral Diagnosis, Oral Pathology Section, Piracicaba Dental School, State University of Campinas, P.O. Box 52 - 13414-903, Piracicaba, SP, Brazil,
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