Document Detail

Angioimmunoblastic lymphadenopathy with dysproteinemia in Thailand.
MedLine Citation:
PMID:  3329519     Owner:  NLM     Status:  MEDLINE    
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a disease of unknown etiology and pathogenesis. It has the features of hyperimmunity and immune deficiency, and its behavior resembles malignant lymphoma. We report a review of 16 patients with AILD seen at Ramathibodi Hospital from 1982 to 1986. Thirteen patients had fever and seven had pruritus and rashes. Lymphadenopathy was found in all 16 cases; generalized in 14 and localized in 2. Hepatomegaly was present in 14 patients while only 7 had splenomegaly. Laboratory findings included autoimmune hemolytic anemia, lymphocytosis and polyclonal hypergammaglobulinemia. Pulmonary involvement was seen in 5 cases, and bone marrow showed the characteristic features of the disease in 9 cases. Two patients went on to develop diffuse lymphocytic, poorly differentiated lymphoma. Fourteen patients were treated with prednisolone initially. Five responded with complete recovery, eight responded with partial recovery, and one died with extensive involvement of the disease. Six of the patients that recovered partially were later treated with cyclophosphamide, vincristine and prednisolone. One patient recovered completely and two partially. Three died from extensive involvement. Two patients with malignant lymphoma were treated by combination chemotherapy. One case went to complete remission while the other died from infection. One patient was lost to follow up before any treatment was started.
S Jootar; P Nitiyanant; S Ratanaprakarn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand     Volume:  5     ISSN:  0125-877X     ISO Abbreviation:  Asian Pac. J. Allergy Immunol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-06-10     Completed Date:  1988-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8402034     Medline TA:  Asian Pac J Allergy Immunol     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols*
Cyclophosphamide / therapeutic use
Dysgammaglobulinemia / etiology
Immunoblastic Lymphadenopathy / blood,  drug therapy,  pathology*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Middle Aged
Precancerous Conditions / pathology
Prednisolone / therapeutic use
Prednisone / therapeutic use
Vincristine / therapeutic use
Reg. No./Substance:
0/COP protocol 2; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 53-03-2/Prednisone; 57-22-7/Vincristine

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