| Angioimmunoblastic T-cell lymphoma and membranous nephropathy: a still unreported association. | |
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MedLine Citation:
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PMID: 20177729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 21-year-old man with lymphadenopathy and Coombs-positive hemolytic anemia had been treated with steroid maintenance therapy. He developed nephrotic syndrome with size increase of lymphadenopathy. Lymph node examination disclosed angioimmunoblastic T-cell lymphoma (AITL). Light microscopy of a renal biopsy specimen showed typical features of membranous nephropathy (MN), such as bubbling appearance and spike formation. Immunofluorescence studies revealed no significant deposition of immunoglobulins. Electron microscopy showed sparse degenerative materials on the epithelial side of the glomerular basement membranes, with intervening spikes. These unique histological findings suggested secondary MN. High-dose steroid therapy followed by six courses of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) therapy improved his symptoms. One-year follow-up revealed the patient in good health without any signs of relapse. Glomerular manifestations have rarely been reported in association with AITL. To our knowledge, this is the first reported case of nephrotic syndrome due to MN associated with AITL. |
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Authors:
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Masaru Togashi; Hideki Wakui; Koya Kodama; Yoshihiro Kameoka; Atsushi Komatsuda; Takashi Nimura; Ryo Ichinohasama; Ken-Ichi Sawada |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-02-23 |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 14 ISSN: 1437-7799 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 288-93 Citation Subset: IM |
Affiliation:
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Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Akita, 010-8543, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Glomerulonephritis, Membranous / complications*, pathology Humans Immunoblastic Lymphadenopathy / complications*, pathology Lymphoma, T-Cell / complications, diagnosis*, drug therapy Male Nephrotic Syndrome / etiology*, pathology Prednisone Vincristine Young Adult |
| Chemical | |
Reg. No./Substance:
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0/CHOP protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine |
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