| Angioimmunoblastic T-cell lymphoma in bone marrow: a morphologic and immunophenotypic study. | |
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MedLine Citation:
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PMID: 19740519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angioimmunoblastic T-cell lymphoma is known to frequently involve bone marrow. However, the histologic and immunophenotypic features of angioimmunoblastic T-cell lymphoma at this site are poorly defined. We assessed 27 bone marrow specimens involved by angioimmunoblastic T-cell lymphoma from 20 patients. Histologically, bone marrow involvement was predominantly multifocal (74%) and exhibited a nodular pattern (78%), often associated with other patterns. Using immunohistochemistry, programed death-1 and CD10 were expressed by atypical lymphocytes in 17 (85%) of 20 and 5 (18.5%) of 27 specimens, respectively. CXCL13 was not expressed by atypical lymphocytes in all cases but did stain stromal cells consistent with follicular dendritic cells in 1 case. BCL-6 as a single antibody was difficult to interpret because many normal bone marrow cells are dimly positive, but BCL-6/CD3 dual staining highlighted BCL-6+ T-cells in all cases assessed. Antibodies specific for CD21 and CD35 did not highlight follicular dendritic cells in any biopsy specimens. Flow cytometry immunophenotyping revealed a CD3+CD10+ T-cell population in 2 (25%) of 8 cases assessed. We conclude that the recognition and classification of angioimmunoblastic T-cell lymphoma in bone marrow are made difficult by the uncommon expression of CD10 (25%), rarity of follicular dendritic cells, and lack of CXCL13 expression at this site. This is most likely attributable to the very different microenvironment of the bone marrow relative to lymph nodes and, in particular, the absence of follicles in bone marrow. By contrast, programed death-1 immunohistochemical staining and double labeling using antibodies specific for BCL-6 and CD3 were helpful in appreciating the follicular T-helper cell immunophenotype of angioimmunoblastic T-cell lymphoma. |
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Authors:
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Faisal A Khokhar; William D Payne; Sameer S Talwalkar; Jeffrey L Jorgensen; Carlos E Bueso-Ramos; L Jeffrey Medeiros; Francisco Vega |
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Publication Detail:
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Type: Journal Article Date: 2009-09-08 |
Journal Detail:
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Title: Human pathology Volume: 41 ISSN: 1532-8392 ISO Abbreviation: Hum. Pathol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2009-12-22 Revised Date: 2011-03-30 |
Medline Journal Info:
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Nlm Unique ID: 9421547 Medline TA: Hum Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Affiliation:
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Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. fvegava@mdanderson.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD / metabolism Bone Marrow Cells / metabolism, pathology* Chemokine CXCL13 / metabolism DNA-Binding Proteins / metabolism Female Flow Cytometry Humans Immunoblastic Lymphadenopathy / metabolism, pathology* Immunophenotyping Intercellular Signaling Peptides and Proteins / metabolism Lymphoma, T-Cell / metabolism, pathology* Male Middle Aged Neprilysin / metabolism Tumor Markers, Biological / metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/B7-DC antigen; 0/BCL6 protein, human; 0/CXCL13 protein, human; 0/Chemokine CXCL13; 0/DNA-Binding Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Tumor Markers, Biological; EC 3.4.24.11/Neprilysin |
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