Document Detail


Angioimmunoblastic T-cell lymphoma: clinical and laboratory features at diagnosis in 77 patients.
MedLine Citation:
PMID:  17873758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We retrospectively analyzed 77 patients with pathologically diagnosed angioimmunoblastic T-cell lymphoma from a single city. There were 43 men and 34 women; the median age was 64.5 years (range, 30-91 yr). Average time between first symptoms of the disease and diagnosis was 3.6 months. At diagnosis, peripheral nodes were present in all but 1 patient, and were generalized in 90% of cases. Constitutional symptoms were reported in 77% of cases and spleen enlargement in 51%. A cutaneous eruption--morbilliform, urticarial, or more polymorphic--was present in 45% of patients; in one-third of them, the eruption occurred after drug administration. Other clinical manifestations included pleuritis (22%); arthralgia or arthritis (17%); ear, nose, and throat involvement (14%); central or peripheral neurologic manifestations (10%); and ascites (5%). Most patients presented with advanced disease at diagnosis (bone marrow involvement in 60% of cases). The main laboratory abnormalities were elevated lactate dehydrogenase levels (71%), inflammatory syndrome (67%), hypergammaglobulinemia (50%), anemia (51%), and lymphopenia (52%). Auto- or disimmune manifestations were reported in one-third of patients: autoimmune hemolytic anemia was present at diagnosis in 19% of patients and thrombocytopenic purpura in 7%. Documented vasculitis was described in 12% of cases. Clonality was analyzed in lymph nodes in 47 patients: T-cell and B-cell clones were found in 45 (96%) and 20 (45%) patients, respectively. Chromosomal abnormalities were identified in 62% of cases: trisomies 3, 5, 18, 19, additional X chromosome, and deletion of chromosome 7 were the most common abnormalities. The current study underlines the diversity of presenting manifestations of angioimmunoblastic T-cell lymphoma.
Authors:
Florence Lachenal; Francoise Berger; Hervé Ghesquières; Pierre Biron; Arnaud Hot; Evelyne Callet-Bauchu; Catherine Chassagne; Bertrand Coiffier; Isabelle Durieu; Hugues Rousset; Gilles Salles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine     Volume:  86     ISSN:  0025-7974     ISO Abbreviation:  Medicine (Baltimore)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2008-03-21     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  2985248R     Medline TA:  Medicine (Baltimore)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-92     Citation Subset:  AIM; IM    
Affiliation:
Hospices Civils de Lyon, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre-Bénite, France. flo.lachenal@free.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Cytological Techniques
Diagnostic Errors
Disease Progression
Female
Follow-Up Studies
Herpesvirus 4, Human / isolation & purification
Humans
Immunoblastic Lymphadenopathy / complications,  diagnosis*,  immunology,  pathology,  virology
Kaplan-Meiers Estimate
Lymphoma, T-Cell, Peripheral / complications,  diagnosis*,  immunology,  pathology,  virology
Male
Middle Aged
Neoplasm Staging
Prognosis
RNA, Viral / analysis
Retrospective Studies
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/RNA, Viral

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