Document Detail


Angiographic results of the first human experience with everolimus-eluting stents for the treatment of coronary lesions (the FUTURE I trial).
MedLine Citation:
PMID:  15619406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to report the angiographic findings of the first human evaluation of the everolimus-eluting stent (EES) for the treatment of noncomplex coronary lesions. Forty-two patients with de novo coronary lesions (2.75 to 4.00 mm vessels; lesion length, <18 mm) were prospectively randomized in a 2:1 ratio to receive either the EES (n = 27) or a metallic stent (n = 15). Baseline clinical and angiographic characteristics were similar among both groups. At 6-month follow-up, EES had a lower in-stent late lumen loss (0.10 +/- 0.22 vs 0.85 +/- 0.32 mm, p <0.0001) and in-segment diameter stenoses (20.7 +/- 12.3% vs 37.0 +/- 15.8%, p = 0.002). There was no in-stent restenosis with EES; however, 1 focal distal edge restenosis was present. There was 1 in-stent and 1 in-segment (proximal edge) restenosis in the metallic stent group. There was no stent thrombosis or aneurysm formation at follow-up in either group.
Authors:
Ricardo A Costa; Alexandra J Lansky; Gary S Mintz; Roxana Mehran; Yoshihiro Tsuchiya; Manuela Negoita; Yael Gilutz; Eugenia Nikolsky; Martin Fahy; Ramona Pop; Ecaterina Cristea; Stephane Carlier; George Dangas; Gregg W Stone; Martin B Leon; Ralf Müller; George Techen; Eberhard Grube
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  95     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-27     Completed Date:  2005-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-6     Citation Subset:  AIM; IM    
Affiliation:
Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York 10022, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Combined Modality Therapy
Coronary Angiography*
Coronary Stenosis / radiography*,  therapy*
Drug Delivery Systems*
Female
Humans
Male
Middle Aged
Prospective Studies
Sirolimus / administration & dosage*,  analogs & derivatives*
Stents*
Chemical
Reg. No./Substance:
159351-69-6/everolimus; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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