Document Detail

Angiographic restenosis after angioplasty: comparison of definitions and correlation with clinical outcome.
MedLine Citation:
PMID:  8269186     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to assess which of the currently used definitions of restenosis most closely indicates degree of recurrence and clinical status by 1) correlating percentage luminal renarrowing with restenosis defined according to each of four definitions, and 2) evaluating which definition was best predicted by clinical recurrence. METHODS: Quantitative angiography in 125 patients was undertaken either at time of early clinical presentation or at 6-month follow-up after percutaneous transluminal coronary angioplasty (PTCA). Absolute luminal diameters measured before and after PTCA and at follow-up were plotted as the percentage return from post-PTCA toward pre-PTCA value. All patients were also defined as restenosed or not restenosed according to each of the four definitions. RESULTS: The angiographic restenosis rate varied from 31% to 47%. Other than for "loss of 50% absolute gain," all definitions defined restenosis in some patients, despite the degree of return from post-PTCA to pre-PTCA value being less than 50%. Early recurrent symptoms predicted angiographic restenosis best, irrespective of angiographic definition, whereas history of recurrent angina or positive exercise testing alone at follow-up were poor predictors (range, 0.46 to 0.54). The predictive value increased (0.75 to 0.87) when exercise testing was positive in patients complaining of angina. The definition "loss of 2 standard deviations" gave the lowest values for positive or negative predictive values irrespective of clinical parameter. CONCLUSIONS: "Loss of 50% absolute gain" may be the best compromise definition. Patients admitted early with angina should undergo recatheterization, whereas exercise tests should be reserved for patients who complain of angina at routine follow-up.
A Gershlick; M J Brack; R S More; D Syndercombe-Court; R Balcon
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Coronary artery disease     Volume:  4     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1994-02-01     Completed Date:  1994-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-81     Citation Subset:  IM    
Academic Department of Cardiology, Groby Road Hospital, London, UK.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Combined Modality Therapy
Coronary Angiography* / drug effects
Coronary Circulation / drug effects
Coronary Disease / radiography,  therapy*
Double-Blind Method
Epoprostenol / administration & dosage*
Follow-Up Studies
Infusions, Intravenous
Middle Aged
Reg. No./Substance:

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