| Angiographic patency study of an albumin-free recombinant streptokinase formulation in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 15576019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Fibrinolytic therapy restores coronary patency and reduces mortality in patients with acute myocardial infarction. Albumin is present in most of the streptokinase formulation as a stabilizer but it is not known whether it plays a role in the product's efficacy and safety profiles. The aim of this study was to assess 90 minutes-coronary patency of a new albumin-free recombinant streptokinase (rSK) formulation. METHODS . Patients with ischemic chest pain and ST-segment elevation, less than 12 hours after symptoms onset, without contraindications for fibrinolytic therapy, were included to receive 1.5 x 10(6) IU of rSK in a one-hour intravenous infusion. Angiography was performed 90 minutes after and coronary patency was classified according to the TIMI flow scales. RESULTS: The study enrolled 25 patients, 59.4 +/- 9.2 years-old, 88% men and 92% white. The mean time interval between the symptoms onset and rSK infusion was 3.0 +/- 2.0 hours. Patency rate (TIMI 2-3) of the infarct-related vessel was 72% (18/25). Partial or complete ST-segment resolution was achieved in 17 patients (68%). Hypotension and nauseas were the most frequent adverse events. Haemorrhage or in-hospital deaths were not reported. CONCLUSIONS: This study suggests that intravenous albumin-free rSK is a safe and appropriate therapy to get early (90-minute) coronary patency in patients with acute myocardial infarction. |
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Authors:
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Lorenzo D Llerena; Juan J Quir?s; Benito Sainz; Jos? A Vald?s; Biolkys Zorio; Luis H Villanueva; C?sar E Filgueiras; Francisco Cabrera; Julio C Echarte; Jes?s M P?rez del Todo; Israel Guerrero; Leonardo L?pez; Ernesto J Garc?a; Betty Nadal; Blas Y Betancourt; Gisou D?az-Rojo; Ana I Garc?a; Pedro L?pez-Saura |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article Date: 2004-11-26 |
Journal Detail:
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Title: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Soci?t? canadienne des sciences pharmaceutiques Volume: 7 ISSN: 1482-1826 ISO Abbreviation: J Pharm Pharm Sci Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-12-03 Completed Date: 2005-10-31 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 9807281 Medline TA: J Pharm Pharm Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 372-7 Citation Subset: IM |
Affiliation:
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Institute for Cardiology and Cardiovascular Surgery, Havana. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Female Humans Male Middle Aged Myocardial Infarction / drug therapy* Pilot Projects Streptokinase / adverse effects, therapeutic use* Thrombolytic Therapy Treatment Outcome Vascular Patency / drug effects |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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