Document Detail

Angiographic patency study of an albumin-free recombinant streptokinase formulation in acute myocardial infarction.
MedLine Citation:
PMID:  15576019     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Fibrinolytic therapy restores coronary patency and reduces mortality in patients with acute myocardial infarction. Albumin is present in most of the streptokinase formulation as a stabilizer but it is not known whether it plays a role in the product's efficacy and safety profiles. The aim of this study was to assess 90 minutes-coronary patency of a new albumin-free recombinant streptokinase (rSK) formulation. METHODS . Patients with ischemic chest pain and ST-segment elevation, less than 12 hours after symptoms onset, without contraindications for fibrinolytic therapy, were included to receive 1.5 x 10(6) IU of rSK in a one-hour intravenous infusion. Angiography was performed 90 minutes after and coronary patency was classified according to the TIMI flow scales. RESULTS: The study enrolled 25 patients, 59.4 +/- 9.2 years-old, 88% men and 92% white. The mean time interval between the symptoms onset and rSK infusion was 3.0 +/- 2.0 hours. Patency rate (TIMI 2-3) of the infarct-related vessel was 72% (18/25). Partial or complete ST-segment resolution was achieved in 17 patients (68%). Hypotension and nauseas were the most frequent adverse events. Haemorrhage or in-hospital deaths were not reported. CONCLUSIONS: This study suggests that intravenous albumin-free rSK is a safe and appropriate therapy to get early (90-minute) coronary patency in patients with acute myocardial infarction.
Lorenzo D Llerena; Juan J Quir?s; Benito Sainz; Jos? A Vald?s; Biolkys Zorio; Luis H Villanueva; C?sar E Filgueiras; Francisco Cabrera; Julio C Echarte; Jes?s M P?rez del Todo; Israel Guerrero; Leonardo L?pez; Ernesto J Garc?a; Betty Nadal; Blas Y Betancourt; Gisou D?az-Rojo; Ana I Garc?a; Pedro L?pez-Saura
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article     Date:  2004-11-26
Journal Detail:
Title:  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Soci?t? canadienne des sciences pharmaceutiques     Volume:  7     ISSN:  1482-1826     ISO Abbreviation:  J Pharm Pharm Sci     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-10-31     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  9807281     Medline TA:  J Pharm Pharm Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  372-7     Citation Subset:  IM    
Institute for Cardiology and Cardiovascular Surgery, Havana.
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MeSH Terms
Acute Disease
Middle Aged
Myocardial Infarction / drug therapy*
Pilot Projects
Streptokinase / adverse effects,  therapeutic use*
Thrombolytic Therapy
Treatment Outcome
Vascular Patency / drug effects
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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