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Angiographic evaluation of the effect of intra-arterial milrinone therapy in patients with vasospasm from aneurysmal subarachnoid hemorrhage.
MedLine Citation:
PMID:  20549498     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Several methods have been used to treat cerebral vasospasm, which is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Here, we examined the effectiveness and safety of intra-arterial injection of milrinone for the treatment of vasospasm.
METHODS: Consecutive patients with angiographically confirmed vasospasm received intra-arterial milrinone between January 2006 and December 2007. The improvement in diameter of vessel (in millimeters) following treatment was assessed by paired t test for statistical significance. The angiographic improvement of supraclinoid internal carotid artery, M1 segment of middle cerebral artery, and A1 and A2 segment of anterior cerebral artery was compared with the modified Rankin score of the patients at discharge.
RESULTS: A total of 15 milrinone treatments were performed in 14 patients (11 females and 3 males) with mean age of 52.7 years (31-68 years). There was significant angiographic improvement after milrinone therapy (p < 0.0001).
CONCLUSION: Intra-arterial milrinone was a safe and effective treatment of cerebral vasospasm following aneurysmal SAH.
Jai Jai Shiva Shankar; Marlise P Dos Santos; Leonardo Deus-Silva; Cheemun Lum
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Publication Detail:
Type:  Journal Article     Date:  2010-06-05
Journal Detail:
Title:  Neuroradiology     Volume:  53     ISSN:  1432-1920     ISO Abbreviation:  Neuroradiology     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Department of Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada.
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