| Angiographic demarcation of an occlusive lesion may predict recanalization after intra-arterial thrombolysis in patients with acute middle cerebral artery occlusion. | |
| | |
MedLine Citation:
|
PMID: 18304033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: The aim of this study is to investigate whether angiographic demarcation of an occlusive lesion may predict successful or failed result of intra-arterial thrombolysis in acute middle cerebral artery (MCA) occlusion. METHODS: We reviewed retrospectively the angiography and clinical data of acute MCA occlusion patients who underwent intra-arterial thrombolysis from 1994 to 2004. Pretreatment angiographic findings at the occlusive lesions were classified as either blurred or sharp, depending on whether the proximal portion of the occlusive lesions had poorly or well demarcated margins. Using uni- or multivariate analysis, recanalization was correlated with our angiographic classification or other clinical variables. RESULTS: Forty-six patients with MCA occlusions underwent intra-arterial thrombolysis during the 10-year period. Forty-four of the angiograms could be classified into one of the two categories: Blurred-type in 20 patients and Sharp-type in 24 patients. Univariate analysis showed a significant association of the classification with recanalization. (Recanalization rate: 95% in Blurred-type and 38% in Sharp-type, P < .0001) Logistic regression analysis showed that the association was independent from other factors (P= .004). CONCLUSION: In acute MCA occlusion, our classification may indicate the difficulty of the recanalization procedure, and may assist in patient triage for different intra-arterial treatment strategies. |
| | |
Authors:
|
Yoshinobu Otsuka; Riichiro Waki; Hiroshi Yamauchi; Seiji Fukazawa; Kaku Kimura; Kotoyuki Shimizu; Hidenao Fukuyama |
Related Documents
:
|
18210143 - Perioperative thrombotic occlusion of left external iliac artery during anterior lumbar... 12195483 - Color doppler appearance of penile cavernosal-spongiosal communications in patients wit... 19268763 - Open-cell versus closed-cell stent design differences in blood flow velocities after ca... |
Publication Detail:
|
Type: Journal Article Date: 2007-11-08 |
Journal Detail:
|
Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 18 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-11-17 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
|
Languages: eng Pagination: 422-7 Citation Subset: IM |
Affiliation:
|
Human Brain Research Center, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan. otsukay@kuhp.kyoto-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Angiography, Digital Subtraction* Carotid Stenosis / drug therapy, radiography Cerebral Angiography* Cerebral Hemorrhage / radiography Female Fibrinolytic Agents / administration & dosage* Humans Infarction, Middle Cerebral Artery / drug therapy*, radiography* Infusions, Intra-Arterial Male Middle Aged Middle Cerebral Artery / radiography Multivariate Analysis Prognosis Retrospective Studies Sensitivity and Specificity Thrombolytic Therapy* Treatment Outcome Urokinase-Type Plasminogen Activator / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Fibrinolytic Agents; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Embolic Doppler ultrasound signal detection using continuous wavelet transform to detect multiple va...
Next Document: Long-term study of brain 1H-MRS study in multiple sclerosis: effect of glatiramer acetate therapy on...