| Angiographic assessment of cardiac allograft vasculopathy: results of a Consensus Conference of the Task Force for Thoracic Organ Transplantation of the German Cardiac Society. | |
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MedLine Citation:
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PMID: 20477994 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Angiograms of cardiac transplant (HTx) recipients were to be evaluated in a ring experiment and a joint consensus on criteria of angiographic evaluation of coronary arteries of HTx patients was to be reached. Twenty-four coronary angiograms from 11 hospitals were circulated. One hundred eighty-eight blinded evaluations were returned. A joint evaluation by six experienced cardiologists was used as reference standard and a consensus evaluation form was developed. Significant lesions (stenosis 75%, 50% in the left main coronary artery) were diagnosed in 10/23 abnormal coronary angiograms (41.7%). Interventional revascularization was recommended in 8/10 (80%). In 21 coronary angiograms distal pruning was found and in 11/21 (52.4%) cases with distal pruning occlusion of at least one peripheral vessel was detected. The best kappa value (0.7) was found for the presence of at least one clinically significant stenosis. Agreement on the site and grade of local stenosis was much less. Some agreement on remodeling was found in assessing diffuse narrowing in the LCA (kappa=0.371, P<0.001). The kappa value for peripheral obliteration was 0.331 (P=0.001). Angiographic evaluation of cardiac allograft vasculopathy, particularly of diffuse and peripheral disease and remodeling, needs standardization. This should be performed in a downward compatible improvement process. |
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Authors:
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Ernst Wellnhofer; Jörg Stypmann; Christoph L Bara; Thomas Stadlbauer; Martin C Heidt; Hans U Kreider-Stempfle; Hae-Young Sohn; Wolfgang Zeh; Thomas Comberg; Siegfried Eckert; Thomas Dengler; Stephan M Ensminger; Nicola E Hiemann |
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Publication Detail:
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Type: Journal Article Date: 2010-08-19 |
Journal Detail:
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Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 23 ISSN: 1432-2277 ISO Abbreviation: Transpl. Int. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: England |
Other Details:
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Languages: eng Pagination: 1094-104 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal compilation © 2010 European Society for Organ Transplantation. |
Affiliation:
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Deutsches Herzzentrum Berlin, Berlin, Germany. wellnhofer@dhzb.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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