Document Detail

Angiographic Outcomes With Early Eptifibatide Therapy in Non-ST-Segment Elevation Acute Coronary Syndrome (from the EARLY ACS Trial).
MedLine Citation:
PMID:  24607027     Owner:  NLM     Status:  Publisher    
Early administration of glycoprotein IIbIIIa inhibitors results in improved angiographic parameters, including thrombolysis in myocardial infarction (TIMI) flow grade, corrected TIMI frame count, and TIMI myocardial perfusion grade (TMPG) among patients with ST-segment elevation myocardial infarction. Whether the same is true in the setting of non-ST-segment elevation acute coronary syndrome is unknown. The goal of the early glycoprotein IIbIIIa inhibition in non-ST-segment elevation acute coronary syndrome (EARLY ACS) angiographic substudy was to compare angiographic outcomes among patients with non-ST-segment elevation acute coronary syndrome who were administered early routine versus delayed provisional eptifibatide. Of 9,406 patients in the EARLY ACS trial, 2,066 patients were included in the angiographic substudy (early routine eptifibatide [n = 1,042] or early placebo [n = 1,024] with delayed provisional eptifibatide after angiography and before percutaneous coronary intervention [PCI]). The angiographic substudy primary end point was the incidence of TMPG 3 before and after PCI. TMPG 3 before (43.7% vs 44.9%, p = 0.58) and after PCI (52.4% vs 50.1%, p = 0.73) was similar for early routine versus delayed provisional eptifibatide, respectively. Angiographic procedural complications consisting of a composite of loss of side branch, abrupt vessel closure, distal embolization, and no reflow occurred less frequently in early routine group versus delayed provisional group (9.3% vs 13.6%, respectively, p = 0.01). In the EARLY ACS angiographic substudy, the use of early routine eptifibatide resulted in fewer angiographic procedural complications. These data provide support for the use of eptifibatide in the catheterization laboratory during high-risk cases merely to prevent angiographic procedural complications.
Vijay Kunadian; Robert P Giugliano; L Kristin Newby; Cafer Zorkun; Jianping Guo; Akshay Bagai; Gilles Montalescot; Eugene Braunwald; Robert M Califf; Frans Van de Werf; Paul W Armstrong; Robert Harrington; C Michael Gibson
Related Documents :
758747 - Comparative effect of counterpulsation and bypass on left ventricular myocardial oxygen...
2096647 - Epicardial oxygen tensions during changes in arterial po2 in pigs.
2521267 - Effect of phosphodiesterase inhibition on myocardial oxygen consumption and coronary bl...
6831777 - Effect of hemodialysis on cardiac performance and transmural myocardial perfusion.
17045677 - Outcome of primary angioplasty for st-segment elevation myocardial infarction during ro...
11485977 - Gene expression and in situ localization of diacylglycerol kinase isozymes in normal an...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-31
Journal Detail:
Title:  The American journal of cardiology     Volume:  -     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Identification of seven Zingiberaceous species based on comparative anatomy of microscopic character...
Next Document:  Mechanisms of Postintervention and Nine-Month Luminal Enlargement After Treatment of Drug-Eluting In...