| Angiographic Demonstration of Neoangiogenesis After Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Diabetic Patients With Critical Limb Ischemia. | |
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MedLine Citation:
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PMID: 22289660 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Critical limb ischemia in diabetic patients is associated with high rates of morbidity and mortality. Suboptimal responses to the available medical and surgical treatments are common in these patients, who also demonstrate limited vascular homeostasis. Neovasculogenesis induced by stem cell therapy could be a useful approach for these patients. Neovasculogenesis and clinical improvement were compared at baseline and at 3 and 12 months after autologous bone marrow-derived mononuclear cell (BMMNC) transplantation in diabetic patients with peripheral artery disease. We conducted a prospective study to evaluate the safety and efficacy of intra-arterial administration of autologous BMMNCs (100-400 × 10(6) cells) in 20 diabetic patients with severe below-the-knee arterial ischemia. Although the time course of clinical effects differed among patients, after 12 months of follow-up all patients presented a notable improvement in the Rutherford-Becker classification, the University of Texas diabetic wound scales, and the Ankle-Brachial Index in the target limb. The clinical outcome was consistent with neovasculogenesis, which was assessed at 3 months by digital subtraction angiography and quantified by MetaMorph software. Unfortunately, local cell therapy in the target limb had no beneficial effect on the high mortality rate in these patients. In diabetic patients with critical limb ischemia, intra-arterial perfusion of BMMNCs is a safe procedure that generates a significant increase in the vascular network in ischemic areas and promotes remarkable clinical improvement. |
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Authors:
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Rafael Ruiz-Salmeron; Antonio de la Cuesta-Diaz; Manuel Constantino-Bermejo; Immaculada Pérez-Camacho; Francisco Marcos-Sánchez; Abdelkrim Hmadcha; Bernat Soria |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell transplantation Volume: 20 ISSN: 1555-3892 ISO Abbreviation: Cell Transplant Publication Date: 2011 |
Date Detail:
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Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208854 Medline TA: Cell Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 1629-39 Citation Subset: IM |
Affiliation:
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Hospitales Universitarios San Lázaro and Virgen Macarena, Sevilla, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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