Document Detail

Angiogenic growth factor responses to long-term treadmill exercise in mice.
MedLine Citation:
PMID:  21675028     Owner:  NLM     Status:  MEDLINE    
We sought to determine whether VEGF and other angiogenic growth factors and their receptors might be subject to negative feedback regulation during two weeks of treadmill-exercise conditioning in inbred strains of mice. C57BL/6 mice exhibited greater VEGF mRNA and protein responses in gastrocnemius muscle to a single bout of treadmill exercise compared to BALB/c mice. The patterns of VEGF, VEGFR1, VEGFR2, Ang2 and Tie2 mRNA expression in gastrocnemius muscles of C57BL/6 mice during long-term exercise support the hypothesis that they may be subject to negative feedback regulation. The combination of expression patterns for growth factors and their receptors suggests that multiple layers of control mechanisms may exist to prevent angiogenesis following a single bout of exercise and to promote angiogenesis following long-term exercise.
Janelle S Pryor; Jean-Pierre Montani; Thomas H Adair
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  54     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-06-15     Completed Date:  2011-06-30     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  309-17     Citation Subset:  IM    
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MeSH Terms
Angiopoietins / genetics*
Mice, Inbred BALB C
Mice, Inbred C57BL
Physical Conditioning, Animal*
RNA, Messenger / analysis
Receptor Protein-Tyrosine Kinases / genetics*
Receptor, TIE-2
Receptors, Vascular Endothelial Growth Factor / genetics*
Vascular Endothelial Growth Factor A / genetics*
Vascular Endothelial Growth Factor Receptor-1 / genetics
Vascular Endothelial Growth Factor Receptor-2 / genetics
Grant Support
Reg. No./Substance:
0/Angiopoietins; 0/RNA, Messenger; 0/Vascular Endothelial Growth Factor A; EC 2.7.1.-/Tek protein, mouse; EC Protein-Tyrosine Kinases; EC, TIE-2; EC, Vascular Endothelial Growth Factor; EC Endothelial Growth Factor Receptor-1; EC Endothelial Growth Factor Receptor-2

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