| Angiogenic growth factor responses to long-term treadmill exercise in mice. | |
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MedLine Citation:
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PMID: 21675028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine whether VEGF and other angiogenic growth factors and their receptors might be subject to negative feedback regulation during two weeks of treadmill-exercise conditioning in inbred strains of mice. C57BL/6 mice exhibited greater VEGF mRNA and protein responses in gastrocnemius muscle to a single bout of treadmill exercise compared to BALB/c mice. The patterns of VEGF, VEGFR1, VEGFR2, Ang2 and Tie2 mRNA expression in gastrocnemius muscles of C57BL/6 mice during long-term exercise support the hypothesis that they may be subject to negative feedback regulation. The combination of expression patterns for growth factors and their receptors suggests that multiple layers of control mechanisms may exist to prevent angiogenesis following a single bout of exercise and to promote angiogenesis following long-term exercise. |
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Authors:
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Janelle S Pryor; Jean-Pierre Montani; Thomas H Adair |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Indian journal of physiology and pharmacology Volume: 54 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 2010 Oct-Dec |
Date Detail:
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Created Date: 2011-06-15 Completed Date: 2011-06-30 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: India |
Other Details:
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Languages: eng Pagination: 309-17 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiopoietins
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genetics* Animals Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Physical Conditioning, Animal* RNA, Messenger / analysis Receptor Protein-Tyrosine Kinases / genetics* Receptors, Vascular Endothelial Growth Factor / genetics* Vascular Endothelial Growth Factor A / genetics* Vascular Endothelial Growth Factor Receptor-1 / genetics Vascular Endothelial Growth Factor Receptor-2 / genetics |
| Grant Support | |
ID/Acronym/Agency:
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HL-51971/HL/NHLBI NIH HHS; P01 HL051971-16/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiopoietins; 0/RNA, Messenger; 0/Vascular Endothelial Growth Factor A; EC 2.7.1.-/Tek protein, mouse; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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