| Angiogenic activity of the recombinant hst-1 protein. | |
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MedLine Citation:
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PMID: 7520355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hst-1 transforming gene encodes a protein which belongs to the FGF family of growth factors. We showed previously that a human hst-1 protein produced in silkworm cells has in vitro mitogenic activity to vascular endothelial cells. Here we report effective synthesis of an unfused human hst-1 protein in E. coli and a potent in vivo angiogenic activity of this hst-1 protein by two in vivo assays for angiogenesis, chick chorioallantoic membrane assay and rat cornea assay. The NIH3T3 transformant transfected with the hst-1 gene appeared to develop a highly-vascularized tumor on nude mice. These data showed that the hst-1 protein has an angiogenic activity in vivo as well as in vitro. |
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Authors:
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T Yoshida; K Ishimaru; H Sakamoto; J Yokota; S Hirohashi; K Igarashi; K Sudo; M Terada |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 83 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-09-22 Completed Date: 1994-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 261-8 Citation Subset: IM |
Affiliation:
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Genetics Division, National Cancer Center Research Institute, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chick Embryo Cornea / blood supply Fibroblast Growth Factor 4 Fibroblast Growth Factors / pharmacology* Mice Mice, Nude Neoplasms, Experimental / blood supply Neovascularization, Pathologic* Proto-Oncogene Proteins / pharmacology* Rats Recombinant Proteins |
| Chemical | |
Reg. No./Substance:
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0/Fgf4 protein, mouse; 0/Fgf4 protein, rat; 0/Fibroblast Growth Factor 4; 0/Proto-Oncogene Proteins; 0/Recombinant Proteins; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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