Document Detail

Angiogenic activity of malignant oral epithelial cells: a preliminary study.
MedLine Citation:
PMID:  2450979     Owner:  NLM     Status:  MEDLINE    
We investigated the angiogenetic capacity of normal and malignant oral epithelial cells by intradermal injection of cells into nude mice. Cells investigated: 1) a tumorigenic cell line from rat palate; 2) a non-tumorigenic epithelial cell line from rat palate; 3) cells from second passage of rat palate epithelium explant cultures; 4) cells from epidermis of neonatal mice. A 0.1 ml suspension containing 10(5) epithelial cells was injected into the flank region. Mice were killed 8 days later to evaluate angiogenesis. Under a dissection microscope, the number of vessels in the skin adjacent to the injection site was counted. The tumorigenic cell line demonstrated the strongest angiogenetic capacity and the non-tumorigenic cell line was more angiogenic than any of the other non-tumorigenic cell types. The greater angiogenic activity of neoplastic oral epithelial cells may be a useful feature in the evaluation of oral malignant development.
D Herwagen; D Arenholt-Bindslev; E Dabelsteen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology     Volume:  16     ISSN:  0300-9777     ISO Abbreviation:  J. Oral Pathol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-04-27     Completed Date:  1988-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342050     Medline TA:  J Oral Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  522-5     Citation Subset:  D; IM    
Department of Oral Diagnosis, Royal Dental College, Copenhagen, Denmark.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*
Cell Line
Mice, Nude
Mouth Mucosa
Mouth Neoplasms / pathology*
Neovascularization, Pathologic*
Precancerous Conditions / pathology*
Skin / blood supply*

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