Document Detail

Angiogenic factors and pregnant woman with new onset seizures.
MedLine Citation:
PMID:  22380455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In patients with new onset seizures during pregnancy, it can be challenging to differentiate between eclampsia and other etiologies. Soluble fms-like tyrosine kinase (sFlt1) is an antiangiogenic protein that is elevated in preeclampsia and eclampsia.
CASE: A multiparous woman presented at 22 weeks gestation with seizures. The initial presentation was highly suspicious for eclampsia, but blood pressure and laboratory data were equivocal. Further investigation suggested primary seizure disorder. Serum sFlt1 was normal for gestational age, supporting the exclusion of eclampsia.
CONCLUSION: History, physical exam, and traditional laboratory data are the mainstays of eclampsia diagnosis; however, sFlt1 may help clinicians when the diagnosis is uncertain at preterm gestational ages.
Hayley Quant; Deborah Arden; Tamara Takoudes; Sarosh Rana
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-01
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  31     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-09-18     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  207-10     Citation Subset:  IM    
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MeSH Terms
Diagnosis, Differential
Eclampsia / diagnosis*
Epilepsy / blood,  diagnosis*
Pregnancy Complications / blood,  diagnosis*
Vascular Endothelial Growth Factor Receptor-1 / blood*
Reg. No./Substance:
EC protein, human; EC Endothelial Growth Factor Receptor-1

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