Document Detail

Angiogenic activity of sera from extrinsic allergic alveolitis patients in relation to clinical, radiological, and functional pulmonary changes.
MedLine Citation:
PMID:  20607270     Owner:  NLM     Status:  MEDLINE    
Extrinsic allergic alveolitis (EAA) caused by inhaled organic environmental allergens can progress to a fibrotic end-stage lung disease. Neovascularization plays an important role in pathogenesis of pulmonary fibrosis. The aim of this study was to assess the effect of sera from EAA patients on the angiogenic capability of normal peripheral human mononuclear cells (MNC) in relation to the clinical, radiological, and functional changes. The study population consisted of 30 EAA patients and 16 healthy volunteers. Routine pulmonary function tests were undertaken using ERS standards. As an angiogenic test, leukocyte-induced angiogenesis assay according to Sidky and Auerbach was used. Compared with sera from healthy volunteers, sera from our EAA patients significantly stimulated angiogenesis (P < 0.001). However, sera from healthy donors also stimulated angiogenesis compared to PBS (P < 0.001). No correlation was found between serum angiogenic activity and clinical symptoms manifested by evaluated patients. A decrease in DLco and in lung compliance in EAA patients was observed but no significant correlation between pulmonary functional tests and serum angiogenic activity measured by the number of microvessels or an angiogenesis index was found. However, the proangiogenic effect of sera from EAA patients differed depending on the stage of the disease and was stronger in patients with fibrotic changes. The present study suggests that angiogenesis plays a role in the pathogenesis of EAA. It could be possible that the increase in the angiogenic activity of sera from EAA patients depends on the phase of the disease.
Tadeusz M Zielonka; Urszula Demkow; Małgorzata Filewska; Beata Bialas; Katarzyna Zycinska; Elzbieta Radzikowska; Andrzej K Wardyn; Ewa Skopinska-Rozewska
Publication Detail:
Type:  Journal Article     Date:  2010-07-06
Journal Detail:
Title:  Lung     Volume:  188     ISSN:  1432-1750     ISO Abbreviation:  Lung     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-80     Citation Subset:  IM    
Department of Family Medicine, Warsaw Medical University, Zwirki i Wigury 61, 02-091 Warsaw, Poland.
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MeSH Terms
Alveolitis, Extrinsic Allergic / blood,  pathology*,  radiography
Mice, Inbred BALB C
Middle Aged
Neovascularization, Pathologic / blood,  pathology*
Pulmonary Fibrosis / blood,  pathology*
Respiratory Function Tests
Young Adult

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