Document Detail


Angiogenesis of the uterus and chorioallantois in the eastern water skink Eulamprus quoyii.
MedLine Citation:
PMID:  20833927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have discovered a modification of the uterus that appears to facilitate maternal-fetal communication during pregnancy in the scincid lizard Eulamprus quoyii. A vessel-dense elliptical area (VDE) on the mesometrial side of the uterus expands as the embryo grows, providing a large vascular area for physiological exchange between mother and embryo. The VDE is already developed in females with newly ovulated eggs, and is situated directly adjacent to the chorioallantois of the embryo when it develops. It is likely that signals from the early developing embryo determine the position of the VDE, as the VDE is off-centre in cases where the embryo sits obliquely in the uterus. The VDE is not a modification of the uterus over the entire chorioallantoic placenta, as the VDE is smaller than the chorioallantois after embryonic stage 33, but expansion of the VDE and growth of the chorioallantois during pregnancy are strongly correlated. The expansion of the VDE is also strongly correlated with embryonic growth and increasing embryonic oxygen demand (Vo2). We propose that angiogenic stimuli are exchanged between the VDE and the chorioallantois in E. quoyii, allowing the simultaneous growth of both tissues.
Authors:
Bridget F Murphy; Scott L Parker; Christopher R Murphy; Michael B Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  213     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3340-7     Citation Subset:  IM    
Affiliation:
Integrative Physiology Research Group, School of Biological Sciences, University of Sydney, Sydney, NSW 2006, Australia. bridget.murphy@sydney.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Chorioallantoic Membrane / blood supply
Female
Lizards / embryology,  physiology*
Neovascularization, Physiologic
Reproduction / physiology
Uterus / blood supply
Viviparity, Nonmammalian / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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