| Angiogenesis, tumor necrosis factor-alpha and procoagulant factors in coronary artery giant aneurysm of a fatal infantile Kawasaki disease. | |
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MedLine Citation:
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PMID: 18402791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Kawasaki disease (KD) is an infantile febrile illness of unknown origin characterized by clinical, laboratory and histopathologic features of systemic vasculitis. METHODS AND RESULTS: We report a 3-month-old female infant with incomplete KD who suddenly died despite intravenous immunoglobulin, aspirin, steroid and heparin treatment. Postmortem examination confirmed the echocardiographically detected giant coronary aneurysms and showed occlusive thrombosis in the giant aneurysm of the left anterior descending coronary artery, associated with neoangiogenesis, macrophage infiltration and immunostaining for tissue factor (a strong initiator of the coagulation cascade), thrombopoietin receptor and tumour necrosis factor-alpha. CONCLUSIONS: These findings show the association of angiogenesis, tumor necrosis factor-alpha and procoagulant factors, with macrophage infiltration in coronary artery aneurysms of a fatal infantile KD. |
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Authors:
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Angela Pucci; Silvana Martino; Angela Celeste; Alessandra Linari; Maria Tibaldi; Elisa Camosso; Maruska Muscio; Giacomo Barattia; Caterina Riva; Giovanni Bartoloni |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-07-05 |
Journal Detail:
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Title: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology Volume: 17 ISSN: 1054-8807 ISO Abbreviation: Cardiovasc. Pathol. Publication Date: 2008 May-Jun |
Date Detail:
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Created Date: 2008-05-09 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9212060 Medline TA: Cardiovasc Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 186-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Regina Margherita Hospital, Turin 10126, Italy. angelapucci@libero.it <angelapucci@libero.it> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation Factors
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biosynthesis* Coronary Aneurysm / etiology*, metabolism, pathology Fatal Outcome Female Humans Immunohistochemistry Infant Macrophages / metabolism, pathology Mucocutaneous Lymph Node Syndrome / complications*, pathology*, physiopathology Myocardium / metabolism, pathology Neovascularization, Pathologic / etiology*, pathology Receptors, Thrombopoietin / biosynthesis Thromboplastin / biosynthesis Tumor Necrosis Factor-alpha / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 0/Receptors, Thrombopoietin; 0/Tumor Necrosis Factor-alpha; 9035-58-9/Thromboplastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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