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Angiogenesis and remodeling in human thoracic aortic aneurysms.
MedLine Citation:
PMID:  25139748     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: Human thoracic aneurysm of the ascending aorta (TAA) is a chronic disease characterized by dilatation of the aortic wall, which can progress to vessel dissection and rupture. TAA has several etiologies but all forms present common features, including tissue remodeling. Here, we determined and characterized the angiogenic process associated with TAA and its relation with wall remodeling.
METHODS AND RESULTS: Immunostaining for blood vessels showed an increased density of microvessels originating from the adventitia in the external medial layer of TAA compared to healthy aortas. Proteomic array analysis of 55 angiogenic factors in medial and adventitial layers showed different expression profiles in both tissue compartments between aneurysmal and healthy aortas. Quantification by ELISA confirmed that all forms of TAA contained higher levels of several pro- and anti-angiogenic factors, including angiopoietin-1 and -2, fibroblast growth factor-a, and thrombospondin-1 than healthy aortas. However, all groups showed comparable levels of VEGF-A. Quantitative RT-PCR demonstrated that angiopoietins were overexpressed in TAA media. Immunostaining and electron microscopy revealed that neovessels had defective endothelial junctions and poor mural cell coverage. This incomplete structure was associated with the accumulation of plasminogen and albumin in the media of TAA.
CONCLUSION: We describe, for the first time, leaky neovessel formation in TAA media in association with an imbalance of angiogenic factor levels. Although the initiating mechanisms of neo-angiogenesis in TAA and the potential etiology-related differences remain to be determined, our results suggest that neo-angiogenesis could participate in TAA wall remodeling and weakening through deposition of blood-borne zymogens.
Authors:
Ketty Kessler; Luciano F Borges; Benoît Ho-Tin-Noé; Guillaume Jondeau; Jean-Baptiste Michel; Roger Vranckx
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-19
Journal Detail:
Title:  Cardiovascular research     Volume:  -     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.
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