| Angiogenesis and placental growth in normal and compromised pregnancies. | |
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MedLine Citation:
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PMID: 11141344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Research on the subject of pre-eclampsia has revolved around placental growth and angiogenesis, as both are central to the aetiology of the disease. Vascular angiogenic growth factor (VEGF) is elevated in pre-eclampsia and correlates with the severity of disease. Its actions in vitro mimic the actions of plasma from women with pre-eclampsia. This chapter examines the available evidence that implicates VEGF in the maternal systemic effects seen in pre-eclampsia, and discusses how an understanding of this growth factor could lead to diagnostic and therapeutic options. Oxygenation status is the unifying concept that surrounds the discussion of placental growth and angiogenesis. The concept that 'hypoxia' is too simplistic a notion to describe pre-eclampsia is discussed. Maldevelopment of the angiogenic process can be assessed by Doppler ultrasound. The future may see a role for magnetic resonance imaging in the identification of poorly perfused placenta. |
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Authors:
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S Ong; G Lash; P N Baker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Baillière's best practice & research. Clinical obstetrics & gynaecology Volume: 14 ISSN: - ISO Abbreviation: Baillieres Best Pract Res Clin Obstet Gynaecol Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-02-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100890322 Medline TA: Baillieres Best Pract Res Clin Obstet Gynaecol Country: England |
Other Details:
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Languages: eng Pagination: 969-80 Citation Subset: IM |
Affiliation:
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School of Human Development, Academic division of Obstetrics and Gynaecology, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inducing Agents
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physiology Endothelial Growth Factors / physiology Female Fetal Hypoxia / physiopathology Humans Lymphokines / physiology Membrane Proteins Neovascularization, Physiologic* Pre-Eclampsia / physiopathology Pregnancy / physiology* Pregnancy Complications / physiopathology* Proteins / physiology Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inducing Agents; 0/Endothelial Growth Factors; 0/Lymphokines; 0/Membrane Proteins; 0/PIGF protein, human; 0/Proteins; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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