Document Detail


Angiogenesis inhibitors in the treatment of small cell and non-small cell lung cancer.
MedLine Citation:
PMID:  15474338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiogenesis is believed to play a critical role in cancer; however, antiangiogenic therapy has not been demonstrated to improve the survival of patients who have lung cancer. In this article, the evidence that supports a role for angiogenesis in the pathogenesis of lung cancer, trials of antiangiogenic agents in lung cancer performed to date, and the lessons learned from these studies are discussed.
Authors:
Fiona H Blackhall; Frances A Shepherd
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hematology/oncology clinics of North America     Volume:  18     ISSN:  0889-8588     ISO Abbreviation:  Hematol. Oncol. Clin. North Am.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-11     Completed Date:  2004-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709473     Medline TA:  Hematol Oncol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1121-41, ix     Citation Subset:  IM    
Affiliation:
Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX England, UK.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / therapeutic use*
Carcinoma, Non-Small-Cell Lung / blood supply,  drug therapy*
Carcinoma, Small Cell / blood supply,  drug therapy*
Clinical Trials as Topic
Humans
Lung Neoplasms / blood supply,  drug therapy*
Neovascularization, Pathologic / prevention & control
Protease Inhibitors / therapeutic use
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Protease Inhibitors; 0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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