Document Detail

Angiogenesis in inflammatory bowel disease.
MedLine Citation:
PMID:  18226040     Owner:  NLM     Status:  MEDLINE    
Both ulcerative colitis and Crohn's disease, the two major forms of inflammatory bowel diseases, are recognized, at the moment, as perplexing and challenging clinical entities, in which several molecules and cell types are implicated. Recent molecular evidence proposes the intestinal microvascular remodelling or angiogenesis, as a phenomenon implicated in the pathogenesis of these chronic inflammatory disorders, together with other proposed theories involved in the pathogenesis of inflammatory bowel diseases, such as genetic, microbacterial and immune factors. Intestinal damage is followed by a physiological angiogenesis, but the abnormal expression of pro- and anti-angiogenic molecules and the changes of vascular cell types could reflect a pathological vascular remodelling. Thus, the inflammation may be favoured and maintained by a pathological angiogenesis. A better understanding of the angiogenic process may facilitate the design of more effective therapies for chronic intestinal inflammation.
I D Pousa; J Maté; J P Gisbert
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  38     ISSN:  1365-2362     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-29     Completed Date:  2008-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-81     Citation Subset:  IM    
Department of Gastroenterology and Ciberehd, University Hospital of La Princesa, Universidad Autónoma Madrid, Spain.
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MeSH Terms
Colitis, Ulcerative / etiology,  pathology*
Crohn Disease / etiology,  pathology*
Endothelial Cells / metabolism
Neovascularization, Pathologic / pathology*
Vascular Endothelial Growth Factors / metabolism
Reg. No./Substance:
0/Vascular Endothelial Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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