| Angiogenesis in chronic rhinosinusitis with nasal polyps and in antrochoanal polyps. | |
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MedLine Citation:
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PMID: 20972696 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES AND STUDY DESIGN: Angiogenesis may be related to the pathogenesis and prognosis of chronic rhinosinusitis with nasal polyposis. This cross-sectional study, in a tertiary university hospital, evaluates angiogenesis parameters in nasal polyps, antrochoanal polyps and middle turbinates. SUBJECTS: Nasal polyps obtained from 24 consecutive patients, were compared to 10 normal middle turbinates and to 11 antrochoanal polyps. METHODS: Analyzing for the expression of the angiogenic marker CD34 by immunohistochemistry. Blood vessels count, vascular surface density and microvessel density were measured by manual and computerized methods. RESULTS: Angiogenesis was significantly higher in nasal polyps compared to control turbinates and to antrochoanal polyps (p = 0.0001 and p = 0.007, respectively). Antrochoanal polyps showed significantly more angiogenesis than normal middle turbinates (p = 0.001). Angiogenesis was not elevated in sub-groups of nasal polyposis patients considered to have worse prognosis. CONCLUSIONS: Angiogenesis probably plays a role in the pathogenesis of both nasal polyposis and antrochoanal polyps. However, the significantly higher angiogenesis found in nasal polyps compared to antrochoanal polyps may support a different mechanism of growth. The lack of difference between angiogenesis and nasal polyposis patients sub-groups, may imply that angiogenesis is not associated with the prognosis of chronic rhinosinusitis with nasal polyposis. |
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Authors:
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Nir Hirshoren; Tzahi Neuman; Menachem Gross; Ron Eliashar |
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Publication Detail:
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Type: Journal Article Date: 2010-10-23 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 60 ISSN: 1420-908X ISO Abbreviation: Inflamm. Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 321-7 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology/Head and Neck Surgery, Hebrew University School of Medicine, Hadassah Medical Center, Hadassah Ein-Kerem, Jerusalem, 91120, Israel, drnir@hadassah.org.il. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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