Document Detail

Angioedema from angiotensin converting enzyme inhibitors: a cause of upper airway obstruction.
MedLine Citation:
PMID:  2233075     Owner:  NLM     Status:  MEDLINE    
Angiotensin-converting enzyme (ACE) inhibitors have several side effects of concern to the otolaryngologist. Angioedema is a rare, but potentially lethal adverse effect when associated with upper airway obstruction. Four cases of ACE-inhibitor-induced angioedema, three with significant upper airway obstruction, are reported. Angioedema secondary to ACE inhibition appears to be mechanism based. The probable link is the potentiation of bradykinin, which results in vasodilation, increased vascular permeability, and angioedema. Since angioedema can progress to upper airway obstruction, otolaryngologists must be aware of this association. The differential diagnosis and treatment of this adverse effect is discussed, as well as a review of ACE inhibitors and other causes of angioedema.
T H Gannon; T L Eby
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  100     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-12     Completed Date:  1990-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1156-60     Citation Subset:  IM    
Department of Surgery, University of Alabama, Birmingham 35233.
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MeSH Terms
Airway Obstruction / chemically induced*,  therapy
Angioedema / chemically induced*,  therapy
Captopril / adverse effects*
Enalapril / adverse effects*
Middle Aged
Tongue Diseases / chemically induced,  therapy
Reg. No./Substance:
62571-86-2/Captopril; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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