| Angioedema from angiotensin converting enzyme inhibitors: a cause of upper airway obstruction. | |
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MedLine Citation:
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PMID: 2233075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin-converting enzyme (ACE) inhibitors have several side effects of concern to the otolaryngologist. Angioedema is a rare, but potentially lethal adverse effect when associated with upper airway obstruction. Four cases of ACE-inhibitor-induced angioedema, three with significant upper airway obstruction, are reported. Angioedema secondary to ACE inhibition appears to be mechanism based. The probable link is the potentiation of bradykinin, which results in vasodilation, increased vascular permeability, and angioedema. Since angioedema can progress to upper airway obstruction, otolaryngologists must be aware of this association. The differential diagnosis and treatment of this adverse effect is discussed, as well as a review of ACE inhibitors and other causes of angioedema. |
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Authors:
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T H Gannon; T L Eby |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Laryngoscope Volume: 100 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1990-12-12 Completed Date: 1990-12-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1156-60 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Alabama, Birmingham 35233. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Obstruction / chemically induced*, therapy Angioedema / chemically induced*, therapy Captopril / adverse effects* Enalapril / adverse effects* Female Humans Male Middle Aged Tongue Diseases / chemically induced, therapy |
| Chemical | |
Reg. No./Substance:
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62571-86-2/Captopril; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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