Document Detail

Angina pectoris: interventional therapies and treatment of restenosis.
MedLine Citation:
PMID:  12818236     Owner:  NLM     Status:  MEDLINE    
Angina pectoris is a clinical syndrome of symptoms caused by myocardial ischaemia due to oxygen demand exceeding supply. The most common cause is coronary artery stenosis due to progressive atherosclerotic disease. Angina has a prevalence of approximately 5% and increases with age. Despite improvements in treatment there remains a yearly mortality of 2-3%. A major advance in the treatment of symptomatic angina was the introduction of percutaneous transluminal coronary angioplasty (PTCA). This initial enthusiasm was dampened by significant numbers developing symptomatic restenosis from vascular elastic recoil and neointimal hyperplasia (NI). The widespread introduction of stent deployment following the initial angioplasty reduced the rates of elastic recoil but failed to prevent NI and may actually stimulate it. Currently, there is much interest in mechanisms that alter cell proliferation thereby decreasing NI. Techniques include brachytherapy, photodynamic therapy and drug-eluting stents. Provisional data for these new stents, which slowly release medication that inhibits cell turnover, are very good with few occurrences of restenosis. Results from larger randomised trials are awaited.
Sunil V Nair; Jean R McEwan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  35     ISSN:  1357-2725     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-05-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1399-406     Citation Subset:  IM    
Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Rayne Building, WC1E 6JJ London, UK.
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MeSH Terms
Angina Pectoris / therapy*
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects
Coronary Angiography
Coronary Restenosis / therapy*
Coronary Thrombosis / etiology,  therapy
Delayed-Action Preparations / therapeutic use
Fibrinolytic Agents / therapeutic use
Long-Term Care
Models, Biological
Platelet Aggregation Inhibitors / therapeutic use
Stents / adverse effects
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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