| Angina: evolution of the role of nitrates. | |
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MedLine Citation:
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PMID: 2117846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent years, concern has been expressed over attenuation of therapeutic effect in patients receiving continuous nitroglycerin therapy for the treatment of angina. Studies have shown that exercise tolerance time does not improve with continuous nitroglycerin regimens, although the frequency of anginal attacks may decrease. Intermittent therapy, which incorporates a nitrate-free interval, improves both exercise time and clinical angina. The optimal duration of the nitrate-free interval has yet to be determined. Future research is likely to focus more on supply-side factors in angina. Of the available antianginal drugs, nitrates have been shown to be highly effective coronary vasodilators, particularly in areas of stenosis. |
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Authors:
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S Scheidt |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Review |
Journal Detail:
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Title: American heart journal Volume: 120 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-09-27 Completed Date: 1990-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 757-61; discussion 769-72 Citation Subset: AIM; IM |
Affiliation:
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New York Hospital-Cornell Medical Center, New York 10021. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
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drug therapy* Exercise Test Humans Nitrates / therapeutic use* Nitroglycerin / administration & dosage, therapeutic use Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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