Document Detail

Angina: evolution of the role of nitrates.
MedLine Citation:
PMID:  2117846     Owner:  NLM     Status:  MEDLINE    
In recent years, concern has been expressed over attenuation of therapeutic effect in patients receiving continuous nitroglycerin therapy for the treatment of angina. Studies have shown that exercise tolerance time does not improve with continuous nitroglycerin regimens, although the frequency of anginal attacks may decrease. Intermittent therapy, which incorporates a nitrate-free interval, improves both exercise time and clinical angina. The optimal duration of the nitrate-free interval has yet to be determined. Future research is likely to focus more on supply-side factors in angina. Of the available antianginal drugs, nitrates have been shown to be highly effective coronary vasodilators, particularly in areas of stenosis.
S Scheidt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Review    
Journal Detail:
Title:  American heart journal     Volume:  120     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  757-61; discussion 769-72     Citation Subset:  AIM; IM    
New York Hospital-Cornell Medical Center, New York 10021.
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MeSH Terms
Angina Pectoris / drug therapy*
Exercise Test
Nitrates / therapeutic use*
Nitroglycerin / administration & dosage,  therapeutic use
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Nitrates; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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