| Angelman's syndrome: a neuropathological study. | |
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MedLine Citation:
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PMID: 1636384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the neuropathological findings of a 3-year-old boy with Angelman's syndrome. The main abnormalities were macroscopic consisting of small temporal and frontal lobes which also showed disorganised and irregular gyri. The occipital lobes appeared flattened but were otherwise normal as were the parietal lobes. The brain stem and cerebellum appeared normal externally. Microscopically there was irregular distribution of neurons in layer 3 and in the cerebral white matter a few subcortical ectopic neurons were present in the temporal and frontal lobes. A single "Purkinje" cell heterotopia was seen but otherwise the cerebellum appeared normal. |
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Authors:
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T Kyriakides; L A Hallam; A Hockey; P Silberstein; B A Kakulas |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta neuropathologica Volume: 83 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-08-21 Completed Date: 1992-08-21 Revised Date: 2007-11-09 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 675-8 Citation Subset: IM |
Affiliation:
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Department of Neuropathology, Royal Perth Hospital, Western Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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pathology* Brain / abnormalities*, pathology Cerebellum / pathology Child, Preschool Dendrites / ultrastructure Electroencephalography Humans Male Syndrome |
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