Document Detail


Aneurysms of coronary arteries in a patient with adult polycystic kidney disease: arteriosclerosis or involvement by the primary disease?
MedLine Citation:
PMID:  8461627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult polycystic kidney disease is frequently associated with gastrointestinal and cardiovascular abnormalities. These include hypertension, mitral valve prolapse, mild dilation of the aortic root, abdominal aneurysms, and predisposition to aortic, mitral, and tricuspidal valve regurgitation reminiscent of Marfan's syndrome. Although the exact molecular mechanisms of adult polycystic kidney disease are not well established, a generalized defect of collagen structure is hypothesized. The most severe vascular problems, however, are typical intracranial aneurysms with a high incidence of subarachnoid hemorrhage and a high mortality rate. We report a case of dilated coronary arteries found incidentally in a patient with adult polycystic kidney disease and stress-induced angina pectoris. The typical angina pectoris of the patient is explained by left ventricular hypertrophy and coronary heart disease. Multiple liver cysts, mitral valve prolapse, and the coronary aneurysms in this patient with adult polycystic kidney disease appear to reflect the manifestation of a generalized connective tissue disorder in this syndrome.
Authors:
M Christ; U Bechtel; S Schnaack; K Theisen; M Wehling
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Clinical investigator     Volume:  71     ISSN:  0941-0198     ISO Abbreviation:  Clin Investig     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-05-04     Completed Date:  1993-05-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9207154     Medline TA:  Clin Investig     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  150-2     Citation Subset:  IM    
Affiliation:
Klinikum Innenstadt, Ludwig-Maximilians-Universität München.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteriosclerosis / complications*,  physiopathology
Coronary Aneurysm / epidemiology,  etiology*,  radiography
Coronary Angiography
Cysts / complications
Humans
Hypertension, Renal / complications,  physiopathology
Kidney Transplantation
Liver Diseases / complications
Male
Mitral Valve Prolapse / complications
Polycystic Kidney Diseases / complications*,  physiopathology,  surgery
Postoperative Complications
Prevalence

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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