Document Detail


Aneurysm and Helicobacter pylori relationship: the seropositivity of CagA, VacA and other antigens of Helicobacter pylori in abdominal and ascending aortic aneurysms.
MedLine Citation:
PMID:  20954441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Helicobacter pylori is thought to be related to atherosclerosis and aneurysm development. We aimed to detect virulance factors of H. pylori and examine the potential etiopathogenetic relationship between aortic aneurysm and H. pylori, 58 abdominal aortic aneurysm (AAA) and 38 ascending aortic aneurysm (AsAA) cases and 57 Healty control group (HCG) were included. We investigated H. pylori IgG by ELISA and virulance factors by Western-Blot (WB) method. No difference was found between AAA (67.24%), AsAA (73.68%) and HCG (57.89%) for H. pylori IgG (p > 0.05). A significant difference was found between AsAA (78.95%) and HCG (57.89%) for H.pylori IgG (p < 0.05) by ELISA and a significant difference was found only between AsAA (100%) and HCG (37.5%) for H. pylori IgG in the 45-55 age group by WB. A statistically significant difference was found between AAA and AsAA for VacA and CagA + VacA and CagA + VacA + UreA antigens and also a significant difference was found between AsAA and HCG for CagA + UreA antigens (p < 0.05). Finally, we suggest that H. pylori VacA has a more important role than CagA in the development of two aneurysms especially in ruptured AAA. New extended studies detecting H. pylori DNA are needed to detect the aetiopathogenesis between aneurysm types and H. pylori.
Authors:
Tevhide Ziver; Pelin Yuksel; Gokhan Ipek; Ibrahim Yekeler; Zehra Bayramoglu; Emin Tireli; Suat Saribas; Mustafa Aslan; Seyma Denli Yalvac; Ibrahim Ozdomanic; Zuhal Torlak; Ahmet Dirican; Muzeyyen Mamal Torun; Bekir Kocazeybek
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The new microbiologica     Volume:  33     ISSN:  1121-7138     ISO Abbreviation:  New Microbiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2010-11-09     Revised Date:  2011-02-25    
Medline Journal Info:
Nlm Unique ID:  9516291     Medline TA:  New Microbiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  233-42     Citation Subset:  IM    
Affiliation:
Microbiology and Clinical Microbiology Department, Cerrahpasa Medical Faculty, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antibodies, Bacterial / blood,  immunology
Antigens, Bacterial / blood,  immunology*
Aortic Aneurysm / blood,  immunology*,  microbiology
Aortic Aneurysm, Abdominal / blood,  immunology,  microbiology
Bacterial Proteins / blood,  immunology*
Cross-Sectional Studies
Female
Helicobacter Infections / blood,  immunology*,  microbiology
Helicobacter pylori / immunology*,  isolation & purification
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Proteins; 0/VacA protein, Helicobacter pylori; 0/cagA protein, Helicobacter pylori

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