| Aneuploidy and progression in promoted preneoplastic foci during chemical hepatocarcinogenesis in the rat. | |
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MedLine Citation:
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PMID: 1671827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since a number of rat hepatocarcinomas are aneuploid, the model DNA content of enzyme-altered foci was determined cytospectrophotometrically, to assess if ploidy changes occur before cancer is established. Male F344 rats treated with diethylnitrosamine and promoted with a choline-deficient, phenobarbital supplemented diet showed in most enzyme-altered foci a multimodal ploidy distribution with diploid, tetraploid and octoploid peaks. A minority of foci, however, exhibited an aneuploid pattern. This change in ploidy reflects irreversible genomic alterations, indicative of tumor progression. Thus, promotion and progression may coexist simultaneously in this model of carcinogenesis, long before hepatomas can be diagnosed. |
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Authors:
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O Sudilovsky; T K Hei |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer letters Volume: 56 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-04-10 Completed Date: 1991-04-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 131-5 Citation Subset: IM |
Affiliation:
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Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy* Animals DNA / analysis DNA, Neoplasm / analysis* Diethylnitrosamine Liver Neoplasms, Experimental / chemically induced, genetics, pathology* Male Precancerous Conditions / chemically induced, genetics, pathology* Rats Rats, Inbred Strains Time Factors Tumor Markers, Biological / analysis gamma-Glutamyltransferase / analysis |
| Grant Support | |
ID/Acronym/Agency:
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CA25164/CA/NCI NIH HHS; CA35362/CA/NCI NIH HHS; CA45716/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Tumor Markers, Biological; 55-18-5/Diethylnitrosamine; 9007-49-2/DNA; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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