Document Detail


Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
MedLine Citation:
PMID:  9413595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The link of aneuploidy and heteroploidy in human solid tumours with early genetic events is poorly understood. The study of human preneoplastic precursor lesions, i.e., colorectal adenomas, chronic ulcerative colitis lesions, and Barrett's esophagus, as considered in this review, appears particularly useful to achieve this aim. Literature data examined here on aneuploidy were obtained by image and flow cytometry, classical cytogenetics, and in situ hybridization based cytogenetics. It appears that aneuploidy is linked with specific gene mutations, i.e., of the tumour suppressor gene p53 in chronic ulcerative colitis and in Barrett's esophagus, and of the protooncogene K-ras in colorectal adenomas. These data and data from experiments using in vitro and mouse models, suggest that chromosome instability, tetraploidization, and asymmetrical chromosome segregation during cell division are the result of deregulated cell cycle genes with multiple functions that normally exert active checks on the cell cycle processes including apoptosis and chromosome stability.
Authors:
W Giaretti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology     Volume:  15     ISSN:  0921-8912     ISO Abbreviation:  Anal Cell Pathol     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-09     Completed Date:  1998-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911016     Medline TA:  Anal Cell Pathol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-117     Citation Subset:  IM    
Affiliation:
Laboratory of Biophysics and Cytometry, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. giaretti@hp380.ist.unige.it
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MeSH Terms
Descriptor/Qualifier:
Adenoma / genetics
Aneuploidy*
Animals
Barrett Esophagus / genetics*
Chromosome Aberrations
Colitis, Ulcerative / genetics
Colorectal Neoplasms / genetics*
Computer Simulation
DNA / metabolism
Genes, p53 / genetics*
Genes, ras / genetics*
Humans
Mice
Mutation
Ploidies
Precancerous Conditions / genetics*
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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