Document Detail

Anesthetic preconditioning decreases arrhythmias and improves regional conduction in isolated hearts.
MedLine Citation:
PMID:  18375323     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Anesthetic preconditioning (APC) is known to protect the heart against necrosis and contractile dysfunction, but protection against arrhythmias has not been well characterized. The authors hypothesized that APC alters the dispersion of electrophysiologic parameters to reduce arrhythmias after global (G) or regional (R) ischemia. DESIGN: Prospective vehicle-controlled study. SETTING: A university research laboratory. SUBJECTS: Langendorff rat hearts (n = 66). INTERVENTIONS: The authors examined the occurrence of arrhythmias, their mean duration, and the magnitude-squared coherence (MSC) of spectral components that provide a quantitative measure of rhythm organization at multiple sites in the heart, expressed as a function of time. Six groups received 0.5 minimum alveolar concentration (MAC) (APC-G, 0.5; APC-R, 0.5, respectively; 0.17 +/- 0.01 mmol/L and 0.18 +/- 0.05 mmol/L) or 1 MAC of isoflurane (APC-G 1.0; APC-R 1.0, respectively, 0.28 +/- 0.02 mmol/L and 0.31 +/- 0.05 mmol/L) before 30 minutes of global (ISC-G) or regional ischemia (ISC-R). Another group (SHAM) was neither subjected to ischemia nor isoflurane. MEASUREMENTS AND MAIN RESULTS: Electrodes were placed on the right atrium, the base, and the apex of the right ventricle. The incidence of ventricular fibrillation (VF) was as follows: ISC-G, 100%; APC-G 0.5, 50%; APC-G 1.0, 40%; ISC-R, 100%; APC-R 0.5, 50%; APC-R 1.0, 50% compared with SHAM 0%. Isoflurane-treated hearts showed delayed onset and decreased duration of arrhythmias on reperfusion. Untreated hearts showed low levels of MSC during reperfusion. In contrast, the isoflurane-treated hearts exhibited moderate-to-high levels of MSC during reperfusion. CONCLUSION: APC reduces the incidence of arrhythmia after global and regional ischemia. In addition, the temporal synchrony of conduction is increased, suggesting a more organized pattern of excitation.
Leo G Kevin; Enis Novalija
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article     Date:  2007-07-30
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  22     ISSN:  1532-8422     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM    
Department of Anesthesiology, The Heart Hospital, London, United Kingdom.
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MeSH Terms
Anesthetics / pharmacology*
Arrhythmias, Cardiac / physiopathology,  prevention & control*
Heart / drug effects,  physiology*
Ischemic Preconditioning, Myocardial / methods*
Myocardial Contraction / drug effects,  physiology*
Prospective Studies
Rats, Wistar
Reg. No./Substance:

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