Document Detail

Anesthetic potency of nitrous oxide in young swine (Sus scrofa).
MedLine Citation:
PMID:  3918491     Owner:  NLM     Status:  MEDLINE    
Determination of nitrous oxide (N2O) potency was accomplished by extrapolation using the concepts of minimum alveolar concentration (MAC) and additivity among inhalation anesthetics. Halothane and isoflurane anesthetic requirement (alveolar concentration) necessary to achieve MAC in 9 pigs decreased with each successive increase in the percentage of inspired N2O (25%, 50%, 75%). Halothane and isoflurane MAC was determined to be 0.94 +/- 0.03 and 1.75 +/- 0.01 volumes percent, respectively. Halothane and isoflurane requirements decreased to 0.74 +/- 0.02, 0.66 +/- 0.02, and 0.58 +/- 0.02; and to 1.56 +/- 0.02, 1.38 +/- 0.02, and 1.08 +/- 0.03 volumes percent with 25%, 50%, and 75% N2O, respectively. The line of best fit derived from regression analysis of the combined data (isoflurane and halothane MAC values) had a correlation coefficient of 0.987 and an X intercept equivalent to 195% N2O. The potency of N2O in pigs was similar to that of other domesticated mammals and reduced halothane and isoflurane anesthetic requirements by approximately 50% of the reduction observed in human beings.
W J Tranquilli; J C Thurmon; G J Benson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  46     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  58-60     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Inhalation / veterinary*
Carbon Dioxide / blood
Drug Interactions
Halothane* / administration & dosage,  analysis
Isoflurane* / administration & dosage,  analysis
Methyl Ethers* / administration & dosage
Nitrous Oxide* / administration & dosage,  analysis
Oxygen / blood
Partial Pressure
Pulmonary Alveoli / analysis
Swine* / physiology
Reg. No./Substance:
0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 151-67-7/Halothane; 26675-46-7/Isoflurane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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