| Anesthetic potency of nitrous oxide in young swine (Sus scrofa). | |
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MedLine Citation:
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PMID: 3918491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Determination of nitrous oxide (N2O) potency was accomplished by extrapolation using the concepts of minimum alveolar concentration (MAC) and additivity among inhalation anesthetics. Halothane and isoflurane anesthetic requirement (alveolar concentration) necessary to achieve MAC in 9 pigs decreased with each successive increase in the percentage of inspired N2O (25%, 50%, 75%). Halothane and isoflurane MAC was determined to be 0.94 +/- 0.03 and 1.75 +/- 0.01 volumes percent, respectively. Halothane and isoflurane requirements decreased to 0.74 +/- 0.02, 0.66 +/- 0.02, and 0.58 +/- 0.02; and to 1.56 +/- 0.02, 1.38 +/- 0.02, and 1.08 +/- 0.03 volumes percent with 25%, 50%, and 75% N2O, respectively. The line of best fit derived from regression analysis of the combined data (isoflurane and halothane MAC values) had a correlation coefficient of 0.987 and an X intercept equivalent to 195% N2O. The potency of N2O in pigs was similar to that of other domesticated mammals and reduced halothane and isoflurane anesthetic requirements by approximately 50% of the reduction observed in human beings. |
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Authors:
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W J Tranquilli; J C Thurmon; G J Benson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 46 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-03-07 Completed Date: 1985-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 58-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Inhalation
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veterinary* Animals Carbon Dioxide / blood Drug Interactions Female Halothane* / administration & dosage, analysis Isoflurane* / administration & dosage, analysis Male Methyl Ethers* / administration & dosage Nitrous Oxide* / administration & dosage, analysis Oxygen / blood Partial Pressure Pulmonary Alveoli / analysis Swine* / physiology |
| Chemical | |
Reg. No./Substance:
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0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 151-67-7/Halothane; 26675-46-7/Isoflurane; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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