| Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy. | |
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MedLine Citation:
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PMID: 17285419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 53-year-old man with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) underwent a gastrectomy. We administered bicarbonated Ringer's solution, which has a physiological concentration of bicarbonate. The level of serum lactate did not increase significantly, and metabolic acidosis did not occur throughout surgery or for 3 h after surgery. Aggressive warming was needed to maintain normothermia, presumably because the mitochondrial respiratory chain, which is responsible for thermogenesis, is impaired in MELAS patients. It is important to maintain normothermia in MELAS patients in order to avoid further mitochondrial metabolic depression. |
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Authors:
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Nobuko Sasano; Yoshihito Fujita; Minhye So; Kazuya Sobue; Hiroshi Sasano; Hirotada Katsuya |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-01-30 |
Journal Detail:
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Title: Journal of anesthesia Volume: 21 ISSN: 0913-8668 ISO Abbreviation: J Anesth Publication Date: 2007 |
Date Detail:
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Created Date: 2007-02-07 Completed Date: 2007-04-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8905667 Medline TA: J Anesth Country: Japan |
Other Details:
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Languages: eng Pagination: 72-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8622, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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administration & dosage Anesthesia / methods* Anesthesia, Epidural / methods Anesthetics, Intravenous / administration & dosage Anesthetics, Local / administration & dosage Blood Gas Analysis / methods Body Temperature / drug effects Diabetes Mellitus, Type 1 / complications Fentanyl / administration & dosage Gastrectomy / methods* Humans Intubation, Intratracheal / methods Isotonic Solutions / administration & dosage Lactic Acid / blood Lidocaine / administration & dosage MELAS Syndrome / complications, surgery* Male Middle Aged Neuromuscular Nondepolarizing Agents / administration & dosage Propofol / administration & dosage Stomach Neoplasms / complications, surgery* Time Factors Vecuronium Bromide / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Anesthetics, Intravenous; 0/Anesthetics, Local; 0/Isotonic Solutions; 0/Neuromuscular Nondepolarizing Agents; 0/bicarbonated Ringer's solution; 137-58-6/Lidocaine; 2078-54-8/Propofol; 437-38-7/Fentanyl; 50-21-5/Lactic Acid; 50700-72-6/Vecuronium Bromide; 84057-95-4/ropivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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