| Anesthetic duration of lidocaine with 10% dextran is comparable to lidocaine with 1:160 000 epinephrine after intraosseous injection in the rabbit. | |
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MedLine Citation:
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PMID: 17618140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effects of 10% dextran and epinephrine on intraosseous injection with lidocaine in rabbits. STUDY DESIGN: Twenty male Japanese white rabbits were used. The effect of intraosseous injection was evaluated using an electromyogram (EMG) of the digastric muscle after electrical pulp stimulation. Two percent lidocaine alone (L), 2% lidocaine containing 1:80000 epinephrine (LE8), 2% lidocaine containing 1:160 000 epinephrine (LE16), and 2% lidocaine containing 10% dextran (LD) were tested. Electromyogram recordings were repeated before and 30 seconds, 1, 2, 3, 4, 5, 7, 10, 12, 15, and 20 minutes after the intraosseous injection. Thereafter, recordings were repeated every 5 minutes until the EMG recovered to the control value. RESULTS: There was no difference in the onset time between the 4 groups. The order of the duration of maximum effect was LE8 >LE16 = LD >or=L. The order of the duration of anesthesia was LE8 >LE16 = LD >L. CONCLUSION: Ten percent dextran potentiates local anesthetic effects of 2% lidocaine in intraosseous injection. The potency of 10% dextran is comparable to 1:160 000 epinephrine. |
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Authors:
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Emiko Ito; Tatsuya Ichinohe; Yoshiyuki Shibukawa; Hidetaka Aida; Yuzuru Kaneko |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-07-06 |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 104 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-21 Completed Date: 2007-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: e26-31 Citation Subset: D; IM |
Affiliation:
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Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan. eito@tdc.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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administration & dosage,
pharmacology* Animals Dextrans / administration & dosage, pharmacology* Electromyography / drug effects Epinephrine / administration & dosage, pharmacology* Infusions, Intraosseous / methods Lidocaine / administration & dosage, pharmacology* Male Plasma Substitutes / administration & dosage, pharmacology* Rabbits Time Factors Vasoconstrictor Agents / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Plasma Substitutes; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 51-43-4/Epinephrine; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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