Document Detail


Anesthesia condition for (18)F-FDG imaging of lung metastasis tumors using small animal PET.
MedLine Citation:
PMID:  18158953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small animal positron emission tomography (PET) with (18)F-FDG has been increasingly used for tumor imaging in the murine model. The aim of this study was to establish the anesthesia condition for imaging of lung metastasis tumor using small animal (18)F-FDG PET. METHODS: To determine the impact of anesthesia on (18)F-FDG distribution in normal mice, five groups were studied under the following conditions: no anesthesia, ketamine and xylazine (Ke/Xy), 0.5% isoflurane (Iso 0.5), 1% isoflurane (Iso 1) and 2% isoflurane (Iso 2). The ex vivo counting, standard uptake value (SUV) image and glucose SUV of (18)F-FDG in various tissues were evaluated. The (18)F-FDG images in the lung metastasis tumor model were obtained under no anesthesia, Ke/Xy and Iso 0.5, and registered with CT image to clarify the tumor region. RESULTS: Blood glucose concentration and muscle uptake of (18)F-FDG in the Ke/Xy group markedly increased more than in the other groups. The Iso 2 group increased (18)F-FDG uptake in heart compared with the other groups. The Iso 0.5 anesthesized group showed the lowest (18)F-FDG uptake in heart and chest wall. The small size of lung metastasis tumor (2 mm) was clearly visualized by (18)F-FDG image with the Iso 0.5 anesthesia. CONCLUSION: Small animal (18)F-FDG PET imaging with Iso 0.5 anesthesia was appropriate for the detection of lung metastasis tumor. To acquire (18)F-FDG PET images with small animal PET, the type and level of anesthetic should be carefully considered to be suitable for the visualization of target tissue in the experimental model.
Authors:
Sang-Keun Woo; Tae Sup Lee; Kyeong Min Kim; June-Youp Kim; Jae Ho Jung; Joo Hyun Kang; Gi Jeong Cheon; Chang Woon Choi; Sang Moo Lim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine and biology     Volume:  35     ISSN:  0969-8051     ISO Abbreviation:  Nucl. Med. Biol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-26     Completed Date:  2008-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304420     Medline TA:  Nucl Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
Affiliation:
Division of Nuclear Medicine and RI Application, Korea Institute of Radiological and Medical Sciences (KIRAMS), Nowon-Gu, Seoul 139-706, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia / methods*
Animals
Female
Fluorodeoxyglucose F18 / diagnostic use*,  metabolism
Lung Neoplasms / radionuclide imaging*,  secondary*
Melanoma, Experimental / pathology,  secondary
Mice
Mice, Inbred C57BL
Positron-Emission Tomography*
Tissue Distribution
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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