Document Detail

'Anergic' T cells modulate the T-cell activating capacity of antigen-presenting cells.
MedLine Citation:
PMID:  10882060     Owner:  NLM     Status:  MEDLINE    
Nowadays there is compelling evidence for immunoregulation by T cells. Recently, we showed that so-called 'anergic' T cells are not functionally inert but can act as regulatory cells by actively suppressing other T cell responses. We now show that 'anergic' T cells mediate this suppressive effect via modulation of the T-cell activating capacity of the antigen-presenting cell (APC). Upon removal of the 'anergic' T cells, the suppressive APC phenotype persisted, indicating that 'anergic' T cells conditioned the APC to become a mediator of T cell suppression. The inhibitory signal delivered by 'anergic' T cells depended on the presence of the cognate ligand for the 'anergic' T cell, and appeared to be dominant since previously activated APC were rendered inhibitory as well. These findings imply that APC upon cross-talk with T cells can adopt distinct functional phenotypes ranging from T-cell stimulatory to T-cell suppressive. The contribution of 'anergic' T cells to the functional tuning of APC offers an explanation for the maintenance of 'anergic' T cells in the repertoire, and for their role in immunoregulation.
L S Taams; E P Boot; W van Eden; M H Wauben
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autoimmunity     Volume:  14     ISSN:  0896-8411     ISO Abbreviation:  J. Autoimmun.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-10-17     Completed Date:  2000-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8812164     Medline TA:  J Autoimmun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  335-41     Citation Subset:  IM    
Institute of Infectious Diseases and Immunology, Department of Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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MeSH Terms
Antigen-Presenting Cells / cytology,  immunology*
CD4-Positive T-Lymphocytes / cytology,  immunology*
Cell Communication / immunology
Clonal Anergy / immunology*
Down-Regulation / immunology
Epitopes, T-Lymphocyte / immunology
Lymphocyte Activation / immunology*
Rats, Inbred Lew
Reg. No./Substance:
0/Epitopes, T-Lymphocyte

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