| Anergic T cells actively suppress T cell responses via the antigen-presenting cell. | |
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MedLine Citation:
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PMID: 9754577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We here show that anergic T cells are active mediators of T cell suppression. In co-culture experiments, we found that anergic T cells, derived from established rat T cell clones and rendered anergic via T cell presentation of the specific antigen (Ag), were active inhibitors of T cell responses. Anergic T cells inhibited not only the responses of T cells with the same Ag specificity as the anergic T cells, but were also capable of efficiently inhibiting polyclonal T cell responses directed to other epitopes. This suppression required close cell-cell contact between antigen-presenting cells (APC), anergic T cells and responder T cells, and only occurred when the epitope recognized by the anergic T cell was present. The suppression was not caused by passive competition for ligands on the APC surface, IL-2 consumption, or cytolysis, and was not mediated by soluble factors derived from anergic T cells that were stimulated with their specific Ag. When responder T cells were added 24 h after co-culturing anergic cells in the presence of Ag and APC, T cell responses were still suppressed, indicating that the suppressive effect was persistently present. However, anergic T cells were not able to suppress responder T cells that had already received a full activation signal. We propose that suppression by anergic T cells is mediated via the APC, either through modulation of the T cell-activating capacity of the APC (APC/T cell interaction), or by inhibition of T cells recognizing their ligand in close proximity on the same APC (T/T cell interaction). |
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Authors:
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L S Taams; A J van Rensen; M C Poelen; C A van Els; A C Besseling; J P Wagenaar; W van Eden; M H Wauben |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of immunology Volume: 28 ISSN: 0014-2980 ISO Abbreviation: Eur. J. Immunol. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-10-13 Completed Date: 1998-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 2902-12 Citation Subset: IM |
Affiliation:
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Institute of Infectious Diseases and Immunology, Department of Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen Presentation* Cell Communication / immunology* Clone Cells Coculture Techniques Lymphocyte Activation* Male Rats Rats, Inbred Lew T-Lymphocyte Subsets / immunology* |
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