| Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. | |
| | |
MedLine Citation:
|
PMID: 11289474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The normochromic normocytic anemia of erythropoietin (EPO) deficiency is recognized in advanced renal failure but not in early renal disease. The aim of this study was to determine whether anemia with EPO deficiency is found in type 1 diabetic patients with diabetic nephropathy in the absence of advanced renal failure and to compare them with patients with nondiabetic renal disease of similar severity. RESEARCH DESIGN AND METHODS: A total of 27 type 1 diabetic patients with diabetic nephropathy (DN), defined as having persistent proteinuria (mean 1,086 mg/day [CI 120-5,1901), a serum creatinine < or = 180 micromol/l, and retinopathy, were compared with 26 nondiabetic patients with glomerulonephritis (GN) and persistent proteinuria (1,874 mg/day [349-5,005]). The Hb concentration, red cell indexes, and serum EPO levels were measured, and other causes for the anemia were excluded. The EPO values were compared with a normal reference range obtained from nondiabetic patients with a microcytic anemia. The DN patients were tested for signs of diabetic peripheral and autonomic neuropathy. RESULTS: We found that 13 of the 27 DN patients were anemic (Hb 10.6 +/- 0.9 g/dl) in marked contrast to none of the GN patients (Hb 13.7 +/- 1.4 g/dl, P < 0.005). In the DN group, serum EPO concentrations failed to increase in response to anemia compared with the response seen in patients with microcytic anemia. Thus, the anemia of the DN group was associated with EPO deficiency. The anemic DN patients showed evidence of more severe proteinuria and diabetic neuropathy than the nonanemic DN patients. CONCLUSIONS: Anemia associated with EPO deficiency can occur early in DN before the onset of advanced renal failure, but does not normally occur in nondiabetic renal disease of similar severity. The pathogenesis requires elucidation. |
| | |
Authors:
|
D R Bosman; A S Winkler; J T Marsden; I C Macdougall; P J Watkins |
Related Documents
:
|
508954 - Erythropoietin in aplastic anemia. 7534714 - Quality of hematologic recovery in patients with aplastic anemia following cyclosporine... 19337174 - Mild subclinical hypothyroidism in thalassaemia major: prevalence, multigated radionucl... 19582174 - Angina pectoris and intensive intravenous iron treatment in hemodialysis patients. 15900374 - Subacute thyroiditis in western saudi arabia. 19877044 - Altered skeletal expression of sclerostin and its link to radiographic progression in a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Diabetes care Volume: 24 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 2001 Mar |
Date Detail:
|
Created Date: 2001-04-05 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
|
Languages: eng Pagination: 495-9 Citation Subset: IM |
Affiliation:
|
King's Diabetes Centre, King's College Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anemia / blood, complications* Biological Markers / blood Blood Pressure Diabetes Mellitus, Type 1 / blood, physiopathology* Diabetic Nephropathies / blood* Erythropoietin / blood*, deficiency Female Heart Rate Hemoglobins / analysis Humans Male Middle Aged Proteinuria Reference Values Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Hemoglobins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjec...
Next Document: Antiatherogenic mitochondrial genotype in patients with type 2 diabetes.