Document Detail


Anemia, leukocytosis and eosinophilia in a resource-poor population with helmintho-ectoparasitic coinfection.
MedLine Citation:
PMID:  21537067     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
INTRODUCTION: Eosinophilia and anemia are very common hematological alterations in the tropics but population-based studies scrutinizing their value for diagnosing parasitic infections are rare.
METHODOLOGY: A cross-sectional study was conducted in a rural district in northeast Brazil where parasitic infections are common. Stool and blood samples were collected and individuals were clinically examined for the presence of ectoparasites.
RESULTS: In total, 874 individuals were examined. Infection with intestinal helminths occurred in 70% (95% CI 67 - 75), infestation with ectoparasites in 45% (95% CI 42 - 49) and co-infection with both helminths and ectoparasites was found in 33% (95% CI 29% - 36%) of all inhabitants. Eosinophil counts ranged from 40/µl to 13.800/µl (median: 900/µl). Haemoglobin levels ranged from 4.8 g/dl to 16.8 g/dl (median: 12.5 g/dl), and anemia was present in 24% of the participants. Leukocytosis was found in 13%, eosinophilia in 74%, and hypereosinophilia in 44% of the participants. Eosinophilia was more pronounced in individuals co-infected with intestinal helminths and ectoparasites (p < 0.001) and correctly predicted parasitic infection in 87% (95% CI 84%-90.7%) of all cases.
CONCLUSIONS: Eosinophilia is strongly associated with the presence of intestinal helminthiases and accentuated by co-infestation with ectoparasites. Our study confirms in a population with high prevalence of intestinal helminthiases and ectoparasites that eosinophilia can be used to accurately diagnose current parasitic infection and initiate treatment.
Authors:
Daniel Pilger; Jörg Heukelbach; Alexander Diederichs; Beate Schlosser; Cinthya Pereira Leite Costa Araújo; Anne Keysers; Oliver Liesenfeld; Hermann Feldmeier
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Publication Detail:
Type:  Journal Article     Date:  2011-04-26
Journal Detail:
Title:  Journal of infection in developing countries     Volume:  5     ISSN:  1972-2680     ISO Abbreviation:  J Infect Dev Ctries     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101305410     Medline TA:  J Infect Dev Ctries     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  260-9     Citation Subset:  IM    
Affiliation:
Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Institute of Microbiology and Hygiene, D-12203 Berlin, Germany. daniel.pilger@charite.de.
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