| Anemia, leukocytosis and eosinophilia in a resource-poor population with helmintho-ectoparasitic coinfection. | |
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MedLine Citation:
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PMID: 21537067 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Eosinophilia and anemia are very common hematological alterations in the tropics but population-based studies scrutinizing their value for diagnosing parasitic infections are rare. METHODOLOGY: A cross-sectional study was conducted in a rural district in northeast Brazil where parasitic infections are common. Stool and blood samples were collected and individuals were clinically examined for the presence of ectoparasites. RESULTS: In total, 874 individuals were examined. Infection with intestinal helminths occurred in 70% (95% CI 67 - 75), infestation with ectoparasites in 45% (95% CI 42 - 49) and co-infection with both helminths and ectoparasites was found in 33% (95% CI 29% - 36%) of all inhabitants. Eosinophil counts ranged from 40/µl to 13.800/µl (median: 900/µl). Haemoglobin levels ranged from 4.8 g/dl to 16.8 g/dl (median: 12.5 g/dl), and anemia was present in 24% of the participants. Leukocytosis was found in 13%, eosinophilia in 74%, and hypereosinophilia in 44% of the participants. Eosinophilia was more pronounced in individuals co-infected with intestinal helminths and ectoparasites (p < 0.001) and correctly predicted parasitic infection in 87% (95% CI 84%-90.7%) of all cases. CONCLUSIONS: Eosinophilia is strongly associated with the presence of intestinal helminthiases and accentuated by co-infestation with ectoparasites. Our study confirms in a population with high prevalence of intestinal helminthiases and ectoparasites that eosinophilia can be used to accurately diagnose current parasitic infection and initiate treatment. |
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Authors:
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Daniel Pilger; Jörg Heukelbach; Alexander Diederichs; Beate Schlosser; Cinthya Pereira Leite Costa Araújo; Anne Keysers; Oliver Liesenfeld; Hermann Feldmeier |
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Publication Detail:
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Type: Journal Article Date: 2011-04-26 |
Journal Detail:
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Title: Journal of infection in developing countries Volume: 5 ISSN: 1972-2680 ISO Abbreviation: J Infect Dev Ctries Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101305410 Medline TA: J Infect Dev Ctries Country: Italy |
Other Details:
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Languages: eng Pagination: 260-9 Citation Subset: IM |
Affiliation:
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Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Institute of Microbiology and Hygiene, D-12203 Berlin, Germany. daniel.pilger@charite.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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