| Anemia, inflammation and health-related quality of life in chronic kidney disease patients. | |
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MedLine Citation:
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PMID: 21612756 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: There is controversy regarding whether an incremental increase in hemoglobin levels is associated with improvements in health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients treated with erythropoiesis-stimulating agents (ESAs). We hypothesized that HRQOL in anemic CKD patients has a multifactorial etiology, including the effects of anemia and inflammation. Methods: 69 non-dialysis CKD patients over 18 years of age with a mean estimated glomerular filtration rate (eGFR) of 43.7 ± 28.8 ml/min/1.73 m2 were divided into anemic and non-anemic cohorts. Kidney disease quality of life (KDQOL) was prospectively recorded using Short Form (SF)-36 components of KDQOL-SF-™ version 1.3 questionnaire. Inflammation was assessed by using a composite of interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α levels in the upper two quartiles. Results: Anemic patients had significantly worse SF-36 components of KDQOL-SF-™ version 1.3, including SF-12 mental component (p = 0.02), role emotional (p = 0.002) and physical function (p = 0.01) compared to patients without anemia. However, in multiple linear regression models, adjusted for GFR, age, gender and inflammatory markers including C-reactive protein (CRP), albumin, ferritin, IL-6, IL-8 and TNF-α, anemia predicted mental components of SF-36 (SF-12 mental component (p = 0.02) and role emotional (p = 0.04)) but not physical components (SF-12 physical component (p > 0.05) and physical function (p > 0.05), supporting the multifactorial nature of reduced HRQOL in anemic patients. Conclusions: Reduced HRQOL in anemic patients is likely related to both anemic and inflammatory status. Prospective studies will be needed to evaluate whether modulating the inflammatory state independent of changes in the hemoglobin concentration improves physical components of HRQOL. |
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Authors:
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Y M K Farag; S R Keithi-Reddy; B V Mittal; S P Surana; F Addabbo; M S Goligorsky; A K Singh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 75 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 524-33 Citation Subset: IM |
Affiliation:
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Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, and Department of Medicine and Department of Pharmacology, Renal Research Institute, New York Medical College, Valhalla, NY, USA *Both the authors have equally contributed to the manuscript and are to acknowledged co-first authors. |
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