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Anemia and inflammation have an additive value in risk stratification of patients undergoing coronary interventions.
MedLine Citation:
PMID:  23846678     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: Anemia and inflammation are both associated with unfavorable outcomes in patients with ischemic heart disease and might be pathophysiologically linked. We aimed to analyze the additive value of anemia and inflammation on the outcomes of patients undergoing percutaneous coronary intervention.
METHODS: Cox regression models were fitted for hemoglobin and C-reactive protein (CRP) cut-offs and performed separately for myocardial infarction (MI) and angina pectoris patients undergoing catheterization at a tertiary hospital between 2006 and 2011. Major adverse cardiovascular events (MACEs) were defined as all-cause mortality, MI and stroke.
RESULTS: Included were 1976 patients (825 with angina pectoris and 1151 with MI). The median follow-up in the MI and the angina pectoris groups was 14 and 13 months, respectively (maximal follow-up of 4 years). In the MI group, the risk of MACE during follow-up was increased with the presence of either anemia (hazard ratio 2.1, P = 0.07) or of elevated CRP (hazard ratio 1.9, P = 0.04), whereas the presence of both increased the risk even further (hazard ratio 3.4, P < 0.01). In the angina pectoris group, the risk of MACE was increased only in patients who had both anemia and elevated CRP (hazard ratio 2.9, P < 0.01).
CONCLUSION: Inflammation and anemia are independently and additively associated with MACE in MI patients.
Authors:
Arie Steinvil; Ori Rogowski; Shmuel Banai; Eran Leshem-Rubinow; Amir Halkin; Gad Keren; Ariel Finkelstein; Noa Mashav; Meital Zuzut; Shlomo Berliner; Yaron Arbel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-10
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  -     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Cardiology bDepartments of Medicine 'D' and 'E', the Tel-Aviv Sourasky Medical Center cSackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel *A. Steinvil and O. Rogowski should be considered as first authors.
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