| Anemia in the preterm infant: erythropoietin versus erythrocyte transfusion--it's not that simple. | |
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MedLine Citation:
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PMID: 19161869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the late 1980s recombinant human erythropoietin (r-EPO) has been studied as an alternative to packed red blood cell (RBC) transfusion for the treatment of anemia of prematurity in very low birth weight infants. Initial trials and reports focused on r-EPO's ability to prevent or treat anemia of prematurity with the goal of eliminating RBC transfusion but achieved limited success. New concerns about the safety of r-EPO administration have emerged. Past cost-benefit analyses of r-EPO administration versus transfusion for the treatment of anemia of prematurity have been nearly balanced. Autologous transfusion, blood-sparing technologies, changes in RBC transfusion technique and safety, and further elucidation of the risk-benefit ratio of r-EPO therapy may change the cost-benefit analysis. |
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Authors:
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Isabelle Von Kohorn; Richard A Ehrenkranz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Clinics in perinatology Volume: 36 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-04-13 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 111-23 Citation Subset: IM |
Affiliation:
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Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8064, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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physiopathology,
therapy* Erythrocyte Transfusion* Erythropoietin, Recombinant / therapeutic use* Hematinics / therapeutic use* Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / therapy* Infant, Very Low Birth Weight |
| Grant Support | |
ID/Acronym/Agency:
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T32 HD007094-32/HD/NICHD NIH HHS; T32HD07094/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 0/Hematinics |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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