Document Detail


Anemia in the preterm infant: erythropoietin versus erythrocyte transfusion--it's not that simple.
MedLine Citation:
PMID:  19161869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the late 1980s recombinant human erythropoietin (r-EPO) has been studied as an alternative to packed red blood cell (RBC) transfusion for the treatment of anemia of prematurity in very low birth weight infants. Initial trials and reports focused on r-EPO's ability to prevent or treat anemia of prematurity with the goal of eliminating RBC transfusion but achieved limited success. New concerns about the safety of r-EPO administration have emerged. Past cost-benefit analyses of r-EPO administration versus transfusion for the treatment of anemia of prematurity have been nearly balanced. Autologous transfusion, blood-sparing technologies, changes in RBC transfusion technique and safety, and further elucidation of the risk-benefit ratio of r-EPO therapy may change the cost-benefit analysis.
Authors:
Isabelle Von Kohorn; Richard A Ehrenkranz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  36     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-04-13     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-23     Citation Subset:  IM    
Affiliation:
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8064, USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia / physiopathology,  therapy*
Erythrocyte Transfusion*
Erythropoietin / therapeutic use*
Hematinics / therapeutic use*
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / therapy*
Infant, Very Low Birth Weight
Recombinant Proteins
Grant Support
ID/Acronym/Agency:
T32 HD007094-32/HD/NICHD NIH HHS; T32HD07094/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Hematinics; 0/Recombinant Proteins; 11096-26-7/Erythropoietin
Comments/Corrections

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