| Anemia in chronic heart failure--clinical and prognostic significance. | |
| | |
MedLine Citation:
|
PMID: 16250861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Anemia is a common finding in chronic heart failure (CHF). Anemia develops due to CHF, but is also known to cause heart failure. Patients with CHF are limited by exercise capacity and fatigue. Low hemoglobin concentration can account for both and may substantially contribute to the symptoms of CHF. Increasing severity of CHF is associated with a higher frequency of anemia, which also becomes clinically more relevant. Anemia has been shown to predict impaired survival in CHF, independent of established prognostic markers. There are many potential reasons for development of anemia in CHF, such as bone marrow depression, reduced intestinal iron uptake and hemodilution as a consequence of sodium and water retention. In most cases, however, anemia in CHF should be viewed as "anemia of chronic illness", being the result of a combination of many factors related to the disease, particularly chronic inflammation. The option of therapeutically targeting anemia in CHF is an intriguing novel approach to improve morbidity and potentially mortality in these patients. |
| | |
Authors:
|
T Karhausen; Stefan D Anker; W Doehner |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current medicinal chemistry. Cardiovascular and hematological agents Volume: 3 ISSN: 1568-0169 ISO Abbreviation: Curr Med Chem Cardiovasc Hematol Agents Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-10-27 Completed Date: 2006-01-23 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101157213 Medline TA: Curr Med Chem Cardiovasc Hematol Agents Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 297-303 Citation Subset: IM |
Affiliation:
|
Div. of Applied Cachexia Research, Dept. of Cardiology, Charité, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia
/
complications*,
epidemiology,
physiopathology Heart Failure / complications* Humans Models, Biological Prognosis Severity of Illness Index Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Homocysteine-lowering treatment in coronary heart disease.
Next Document: Recent progress in signal transduction research of the angiotensin II type-1 receptor: protein kinas...