| Anemia in Crohn's disease. Importance of inadequate erythropoietin production and iron deficiency. | |
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MedLine Citation:
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PMID: 8082499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal blood loss as well as chronic inflammation are regarded as the most important mechanisms in the pathogenesis of anemia in Crohn's disease. In addition, cytokines such as interleukin-6 can suppress erythropoietin production. This study was performed to investigate the importance of iron status, inflammatory activity, and endogenous erythropoietin concentrations for the development of anemia in Crohn's disease. In 49 consecutive patients with Crohn's disease, hemoglobin, inflammatory activity (Crohn's disease activity index, C-reactive protein, alpha 1-acid glycoprotein), iron status (serum iron, transferrin, transferrin saturation, ferritin), and serum erythropoietin levels were studied. Anemic (Hb < 12.0 g/dl; N = 16) vs nonanemic patients (Hb > or = 12 g/dl; N = 33) showed reduced iron compartments (eg, ferritin 28.7 +/- 12.9 micrograms/liter vs 63.2 +/- 15.0 micrograms/liter, transferrin saturation 6.2 +/- 1.4% vs 11.5 +/- 1.3%, P < 0.01) but no differences in inflammatory activity. An inverse correlation between erythropoietin and hemoglobin concentrations was found (r = -0.62; P < 0.001), but the increase in erythropoietin levels was inadequate to the degree of anemia. There was no correlation between erythropoietin and interleukin-6 serum levels. Four of five anemic patients with hemoglobin below 10.5 g/dl and erythropoietin levels within the normal range were treated with parenteral iron (200 mg iron saccharate in 250 ml NaCl, weekly, intravenously). Two of them additionally received recombinant human erythropoietin (150 units/kg, 3x weekly, subcutaneously). After five weeks all patients had a marked increase in hemoglobin. However, the mean increase in erythropoietin-treated patients was 5.0 g/dl compared to 2.0 g/dl in the patients with iron therapy only.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C Gasché; W Reinisch; H Lochs; B Parsaei; S Bakos; J Wyatt; G F Fueger; A Gangl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 39 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-10-13 Completed Date: 1994-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1930-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Gastroenterology and Hepatology, University of Vienna, Austria. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / drug therapy, etiology* Crohn Disease / blood, complications* Drug Therapy, Combination Erythropoietin / metabolism*, therapeutic use Female Ferritins / blood Humans Interleukin-6 / blood Iron / deficiency*, therapeutic use Male Middle Aged Recombinant Proteins |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Recombinant Proteins; 11096-26-7/Erythropoietin; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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