Document Detail

Anemia and end-stage renal disease in the developing world.
MedLine Citation:
PMID:  12197929     Owner:  NLM     Status:  MEDLINE    
In developing countries, multiple comorbidities such as malnutrition, parasitoses, and hemoglobinopathies contribute to the aggravation of anemia observed in patients with end-stage renal diseases. We analyze here the results of a retrospective evaluation of red-cells indices and iron parameters conducted at the end of December 2000 in 304 prevalent Tunisian patients (sex ratio, 1.05; mean age, 53.7 years) receiving chronic hemodialysis for a median duration of 49.6 months (range, 1.6 to 278). Anemia, observed in 87.8% of patients, was normochromic and normocytic in 73% of cases. Only 2% of patients had microcytic and hypochromic anemia. Iron deficiency was observed in 21.6% of anemic patients. The mean rate of hemoglobin was significantly higher in men and in patients with polycystic kidney disease as the cause of renal failure. There was a positive correlation between hemoglobin values and the quality of dialysis. Only 10.8% of patients were on recombinant human erythropoietin (rHuEPO) and 38% required regular transfusions. We conclude that anemia observed in our patients had, in most cases, the characteristics of renal anemia and could be attributed to a deficit of renal production of erythropoietin. However, for financial reasons, prescription of rHuEPO is rather restrictive and blood transfusion remains largely used. The nephrology community and dialysis providers should increase their efforts to improve the anemia care of dialyzed patients in developing countries.
Hédi Ben Maïz; Ezzeddine Abderrahim; Karim Zouaghi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  26     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-28     Completed Date:  2003-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  760-4     Citation Subset:  IM    
Department of Nephrology and Internal Medicine, Charles Nicolle Hospital, Tunis, Tunisia.
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MeSH Terms
Aged, 80 and over
Anemia / complications*,  diagnosis,  epidemiology*,  therapy
Blood Transfusion
Developing Countries*
Erythrocyte Indices
Erythropoietin, Recombinant / therapeutic use
Iron / blood
Kidney Failure, Chronic / complications*,  epidemiology*,  therapy
Middle Aged
Renal Dialysis
Retrospective Studies
Tunisia / epidemiology
Reg. No./Substance:
0/Erythropoietin, Recombinant; 7439-89-6/Iron

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