Document Detail

Anemia and cardiovascular disease, hospitalization, end stage renal disease, and death in older patients with chronic kidney disease.
MedLine Citation:
PMID:  16142575     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Large observational studies examining the association between anemia and "hard" clinical outcomes are rare in patients with chronic kidney disease (CKD). METHODS: We used the General Medicare 5% Denominator Files to identify patients aged 67 years or more with CKD on December 31, 1999. Outcomes in the ensuing 2 years were compared in patients with and those without anemia (entry period, 1998-1999; follow-up period, 2000-2001). RESULTS: Of 41,522 CKD patients identified, 49.0% had claims of anemia diagnosis. The factors associated (p< 0.0001) with anemia included older age, female gender, black race, and all 10 comorbid conditions studied; adjusted odds ratios (ORs) exceeded 1.5 for age 80 years old or older (OR, 1.54 compared to <70 years), for black race (OR, 1.52), and for co-existing diagnoses of congestive heart failure (OR, 1.64), gastrointestinal bleeding (OR, 3.65), and liver disease (OR, 2.16). During the follow-up period, outcome event rates (expressed per 1000 patient-years) were as follows: renal replacement therapy, 23.5; death, 186.4; congestive heart failure, 390.0; atherosclerotic vascular disease, 410.5; and first hospitalization, 552.6. Using proportional hazards modeling, the presence of anemia was associated (p < 0.0001) with the following adjusted hazards ratios: atherosclerotic vascular disease, 1.09; congestive heart failure, 1.14; renal replacement therapy, 2.61 and death, 1.40. CONCLUSION: A diagnosis of anemia is present in nearly half of all patients with CKD, aged 67 years or more, a group at very high risk of cardiovascular disease, hospitalization, end-stage renal disease, and death. Anemia is associated with each of these events.
Shuling Li; Robert N Foley; Allan J Collins
Related Documents :
19782835 - Cardiac screening before noncardiac surgery.
11527485 - Cognitive impairment and mortality in older primary care patients.
18520715 - Management of acute coronary syndromes in patients with renal dysfunction.
9122515 - Body mass index and mortality in patients with severe alpha 1-antitrypsin deficiency.
3605185 - Significance of blood lactate levels in critically ill patients with liver disease.
6135705 - Inhibition of thyrotropin-induced adenosine 3'5'-monophosphate increase by immunoglobul...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International urology and nephrology     Volume:  37     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-05     Completed Date:  2006-04-10     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  395-402     Citation Subset:  IM    
Nephrology Analytical Services, Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Anemia / etiology*
Chronic Disease
Cohort Studies
Follow-Up Studies
Kidney Diseases / complications*,  mortality,  therapy
Kidney Failure, Chronic / etiology*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Peritoneal catheters and related infections.
Next Document:  Sobh formula: a new formula for estimation of creatinine clearance in healthy subjects and patients ...